Preclinical models of congestive heart failure, advantages, and limitations for application in clinical practice

M Saura, JL Zamorano, C Zaragoza - Frontiers in physiology, 2022 - frontiersin.org
Congestive heart failure (CHF) has increased over the years, in part because of recent
progress in the management of chronic diseases, thus contributing to the maintenance of an …

Pulmonary artery banding in sheep: a novel large animal model for congestive hepatopathy

R Ukita, WK Wu, J Liang… - Journal of Applied …, 2023 - journals.physiology.org
Congestive hepatopathy is becoming increasingly recognized among Fontan-palliated
patients. Elevated central venous pressure is thought to drive the pathologic progression …

Large animal preclinical investigation into the optimal extracorporeal life support configuration for pulmonary hypertension and right ventricular failure

R Ukita, JW Stokes, WK Wu, YJ Patel… - The Journal of Heart and …, 2023 - Elsevier
Introduction Right ventricular failure (RVF) is a major cause of mortality in pulmonary
hypertension (PH). Mechanical circulatory support holds promise for patients with medically …

A large animal model for pulmonary hypertension and right ventricular failure: left pulmonary artery ligation and progressive main pulmonary artery banding in sheep

R Ukita, JW Stokes, WK Wu, J Talackine… - JoVE (Journal of …, 2021 - jove.com
Decompensated right ventricular failure (RVF) in pulmonary hypertension (PH) is fatal, with
limited medical treatment options. Developing and testing novel therapeutics for PH requires …

Ambulatory 7-day mechanical circulatory support in sheep model of pulmonary hypertension and right heart failure

R Ukita, YJ Patel, WK Wu, SA Francois… - The Journal of Heart and …, 2024 - Elsevier
Background Right heart failure is the major cause of death in pulmonary hypertension. Lung
transplantation is the only long-term treatment option for patients who fail medical therapy …

Progression toward decompensated right ventricular failure in the ovine pulmonary hypertension model

R Ukita, A Tumen, JW Stokes, C Pinelli, KR Finnie… - ASAIO …, 2022 - journals.lww.com
Decompensated right ventricular failure (RVF) in patients with pulmonary hypertension (PH)
is fatal, with limited treatment options. Novel mechanical circulatory support systems have …

Swine Model of Myocardial Infarction Induced by Ischemia-Reperfusion and Embolization

R Mazurek, O Bikou, K Ishikawa - Experimental Models of Cardiovascular …, 2024 - Springer
Acute myocardial infarction continues to account for a growing burden of heart failure
worldwide. Despite existing therapies, new approaches for reducing the extent of damage …

A Dynamic Sheep Model to Induce Pulmonary Hypertension and Right Ventricular Failure

CA Johnson Jr, M Cortelli Jr, G Glomp… - Experimental Models of …, 2024 - Springer
Decompensated right ventricular failure (RVF) in pulmonary hypertension (PH) is fatal, with
limited medical treatment options. Developing and testing novel therapeutics for PH requires …

Establishment of mouse models for severe pulmonary hypertension through 'double‐hit'strategies

L Chen, X Chen, Y Huang, Z Ma, X Zeng… - Experimental …, 2024 - Wiley Online Library
Mouse models are crucial for understanding pulmonary hypertension (PH) mechanisms and
developing therapies, but existing mouse models under hypoxia only exhibit mild PH. To …