Fibroblast-like synoviocytes or synovial fibroblasts (FLS) are important cellular components
of the inner layer of the joint capsule, referred to as the synovial membrane. They can be …

Fibroblast-like synoviocytes (FLSs) are important non-immune cells located mostly in the
inner layer of the synovium. Indeed, these cells are specialized mesenchymal cells …

Proteoglycans are a specific subset of glycoproteins found at the cell surface and in the
extracellular matrix, where they interact with a plethora of proteins involved in metabolic …

Non-communicable chronic diseases (NCDs) are nowadays the principal cause of death,
especially in most industrialized nations. These illnesses have increased exponentially with …

The syndecans are the major family of transmembrane proteoglycans, usually bearing
multiple heparan sulfate chains. They are present on virtually all nucleated cells of …

Exosomes, as cell–cell communicators with an endosomal origin, are involved in the
progression of various diseases. RAB5A, a member of the small Rab GTPases family, which …

Dexamethasone (Dex) exhibits broad-spectrum anti-inflammatory effects in chronic
destructive rheumatoid arthritis. We present in vivo and in vitro evidence supporting the …

Abstract Background Cardiovascular diseases (CVDs) are a significant cause of mortality
worldwide and are characterized by severe atherosclerosis (AS) in patients. However, the …

Background: Pulmonary arterial hypertension (PAH) is a progressive disease characterized
by pulmonary vascular remodeling. The development of PAH involves N6-methyladenosine …

Vascular endothelial cell dysfunction involving syndecan (SDC) proteoglycans contributes to
acute sepsis-associated lung injury (ALI), but the exact SDC isoform involved is unclear. We …