The role of adult hippocampal neurogenesis in brain health and disease
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …
Environmental enrichment, new neurons and the neurobiology of individuality
G Kempermann - Nature Reviews Neuroscience, 2019 - nature.com
Abstract 'Enriched environments' are a key experimental paradigm to decipher how
interactions between genes and environment change the structure and function of the brain …
interactions between genes and environment change the structure and function of the brain …
Adult hippocampal neurogenesis and cognitive flexibility—linking memory and mood
Adult hippocampal neurogenesis has been implicated in cognitive processes, such as
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …
Regulation and function of adult neurogenesis: from genes to cognition
Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness
and potential impact on cognition but also to its localized vertical integration of different …
and potential impact on cognition but also to its localized vertical integration of different …
Adult neurogenesis contributes to hippocampal plasticity
Adult hippocampal neurogenesis is the process by which new functional neurons are added
to the adult dentate gyrus of the hippocampus. Animal studies have shown that the degree of …
to the adult dentate gyrus of the hippocampus. Animal studies have shown that the degree of …
Recalibrating the relevance of adult neurogenesis
JS Snyder - Trends in neurosciences, 2019 - cell.com
Conflicting reports about whether adult hippocampal neurogenesis occurs in humans raise
questions about its significance for human health and the relevance of animal models …
questions about its significance for human health and the relevance of animal models …
[HTML][HTML] Re-evaluating circuit mechanisms underlying pattern separation
NA Cayco-Gajic, RA Silver - Neuron, 2019 - cell.com
When animals interact with complex environments, their neural circuits must separate
overlapping patterns of activity that represent sensory and motor information. Pattern …
overlapping patterns of activity that represent sensory and motor information. Pattern …
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
The integration of adult-born neurons into the circuitry of the adult hippocampus suggests an
important role for adult hippocampal neurogenesis in learning and memory, but its specific …
important role for adult hippocampal neurogenesis in learning and memory, but its specific …
[HTML][HTML] Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion
T Nakashiba, JD Cushman, KA Pelkey, S Renaudineau… - Cell, 2012 - cell.com
Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate
gyrus, are highly active during the first few weeks after functional integration into the …
gyrus, are highly active during the first few weeks after functional integration into the …
[HTML][HTML] Mechanisms and functional implications of adult neurogenesis
C Zhao, W Deng, FH Gage - Cell, 2008 - cell.com
The generation of new neurons is sustained throughout adulthood in the mammalian brain
due to the proliferation and differentiation of adult neural stem cells. In this review, we …
due to the proliferation and differentiation of adult neural stem cells. In this review, we …