The role of adult hippocampal neurogenesis in brain health and disease

T Toda, SL Parylak, SB Linker, FH Gage - Molecular psychiatry, 2019 - nature.com
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

Environmental enrichment, new neurons and the neurobiology of individuality

G Kempermann - Nature Reviews Neuroscience, 2019 - nature.com
Abstract 'Enriched environments' are a key experimental paradigm to decipher how
interactions between genes and environment change the structure and function of the brain …

Adult hippocampal neurogenesis and cognitive flexibility—linking memory and mood

C Anacker, R Hen - Nature Reviews Neuroscience, 2017 - nature.com
Adult hippocampal neurogenesis has been implicated in cognitive processes, such as
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …

Regulation and function of adult neurogenesis: from genes to cognition

JB Aimone, Y Li, SW Lee… - Physiological …, 2014 - journals.physiology.org
Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness
and potential impact on cognition but also to its localized vertical integration of different …

Adult neurogenesis contributes to hippocampal plasticity

T Toda, FH Gage - Cell and tissue research, 2018 - Springer
Adult hippocampal neurogenesis is the process by which new functional neurons are added
to the adult dentate gyrus of the hippocampus. Animal studies have shown that the degree of …

Recalibrating the relevance of adult neurogenesis

JS Snyder - Trends in neurosciences, 2019 - cell.com
Conflicting reports about whether adult hippocampal neurogenesis occurs in humans raise
questions about its significance for human health and the relevance of animal models …

[HTML][HTML] Re-evaluating circuit mechanisms underlying pattern separation

NA Cayco-Gajic, RA Silver - Neuron, 2019 - cell.com
When animals interact with complex environments, their neural circuits must separate
overlapping patterns of activity that represent sensory and motor information. Pattern …

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

W Deng, JB Aimone, FH Gage - Nature reviews neuroscience, 2010 - nature.com
The integration of adult-born neurons into the circuitry of the adult hippocampus suggests an
important role for adult hippocampal neurogenesis in learning and memory, but its specific …

[HTML][HTML] Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion

T Nakashiba, JD Cushman, KA Pelkey, S Renaudineau… - Cell, 2012 - cell.com
Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate
gyrus, are highly active during the first few weeks after functional integration into the …

[HTML][HTML] Mechanisms and functional implications of adult neurogenesis

C Zhao, W Deng, FH Gage - Cell, 2008 - cell.com
The generation of new neurons is sustained throughout adulthood in the mammalian brain
due to the proliferation and differentiation of adult neural stem cells. In this review, we …