Uropathogenic Escherichia coli (UPEC)-Associated Urinary Tract Infections: The Molecular Basis for Challenges to Effective Treatment

S Whelan, B Lucey, K Finn - Microorganisms, 2023 - mdpi.com
Urinary tract infections (UTIs) are among the most common bacterial infections, especially
among women and older adults, leading to a significant global healthcare cost burden …

Uropathogen and host responses in pyelonephritis

L Schwartz, J de Dios Ruiz-Rosado… - Nature Reviews …, 2023 - nature.com
Urinary tract infections (UTIs) are among the most common bacterial infections seen in
clinical practice. The ascent of UTI-causing pathogens to the kidneys results in …

Polypharmacological cell-penetrating peptides from venomous marine animals based on immunomodulating, antimicrobial, and anticancer properties

S Hemmati, H Rasekhi Kazerooni - Marine Drugs, 2022 - mdpi.com
Complex pathological diseases, such as cancer, infection, and Alzheimer's, need to be
targeted by multipronged curative. Various omics technologies, with a high rate of data …

Exosomes derived from bladder epithelial cells infected with uropathogenic Escherichia coli increase the severity of urinary tract infections (UTIs) by impairing …

Z Wang, Z Jiang, Y Zhang, C Wang, Z Liu, Z Jia… - PLoS …, 2024 - journals.plos.org
Uropathogenic Escherichia coli (UPEC) is the primary causative agent of urinary tract
infections (UTIs) in humans. Moreover, as one of the most common bacterial pathogens …

N-acetylcysteine prevents catheter occlusion and inflammation in catheter associated-urinary tract infections by suppressing urease activity

A Manoharan, J Farrell, VR Aldilla… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction Proteus mirabilis is a key pathobiont in catheter-associated urinary tract
infections (CA-UTIs), which is well known to form crystalline biofilms that occlude catheters …

Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics

MR Timm, SK Russell, SJ Hultgren - Nature Reviews Microbiology, 2024 - nature.com
Urinary tract infections (UTIs), which include any infection of the urethra, bladder or kidneys,
account for an estimated 400 million infections and billions of dollars in health-care …

A Modified small intestinal submucosa patch with multifunction to promote scarless repair and reinvigoration of urethra

LP Huang, Y Liu, QJ Li, WQ Zhang… - Advanced …, 2023 - Wiley Online Library
To reconstruct and restore the functions of the male urethra is a challenging task for
urologists. The acellular matrix graft currently used in the clinics is mono‐functional and may …

Collectin 11 has a pivotal role in host defense against kidney and bladder infection in mice

KY Wu, B Cao, WB Chen, W Wu, S Zhao, XY Min… - Kidney International, 2024 - Elsevier
The urinary tract is constantly exposed to microorganisms. Host defense mechanisms in
protection from microbial colonization and development of urinary tract infections require …

Neutrophil extracellular traps in urinary tract infection

K Krivošíková, N Šupčíková, A Gaál Kovalčíková… - Frontiers in …, 2023 - frontiersin.org
Background Urinary tract infections (UTI) are common types of bacterial infection in children.
UTI treatment is aimed to prevent complications including hypertension, proteinuria, and …

Biomarkers for urinary tract infection: present and future perspectives

TK Mattoo, JD Spencer - Pediatric Nephrology, 2024 - Springer
A prompt diagnosis of urinary tract infection (UTI) is necessary to minimize its symptoms and
limit sequelae. The current UTI screening by urine test strip analysis and microscopic …