The immune contexture in cancer prognosis and treatment
Immunotherapy is currently the most rapidly advancing area of clinical oncology, and
provides the unprecedented opportunity to effectively treat, and even cure, several …
provides the unprecedented opportunity to effectively treat, and even cure, several …
Photodynamic therapy for metastatic melanoma treatment: A review
C Naidoo, CA Kruger… - Technology in cancer …, 2018 - journals.sagepub.com
This review article is based on specifically targeted nanoparticles that have been used in the
treatment of melanoma. According to the Skin Cancer Foundation, within 2017 an estimated …
treatment of melanoma. According to the Skin Cancer Foundation, within 2017 an estimated …
[HTML][HTML] Conserved pan-cancer microenvironment subtypes predict response to immunotherapy
The clinical use of molecular targeted therapy is rapidly evolving but has primarily focused
on genomic alterations. Transcriptomic analysis offers an opportunity to dissect the …
on genomic alterations. Transcriptomic analysis offers an opportunity to dissect the …
Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation
W Lin, L Chen, H Zhang, X Qiu, Q Huang… - Nature …, 2023 - nature.com
The recently described role of RNA methylation in regulating immune cell infiltration into
tumors has attracted interest, given its potential impact on immunotherapy response …
tumors has attracted interest, given its potential impact on immunotherapy response …
Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma
Adoptive T-cell therapy (ACT) is a highly intensive immunotherapy regime that has yielded
remarkable response rates and many durable responses in clinical trials in melanoma; …
remarkable response rates and many durable responses in clinical trials in melanoma; …
Immune cell gene signatures for profiling the microenvironment of solid tumors
The immune composition of the tumor microenvironment regulates processes including
angiogenesis, metastasis, and the response to drugs or immunotherapy. To facilitate the …
angiogenesis, metastasis, and the response to drugs or immunotherapy. To facilitate the …
Stepwise-edited, human melanoma models reveal mutations' effect on tumor and microenvironment
Establishing causal relationships between genetic alterations of human cancers and specific
phenotypes of malignancy remains a challenge. We sequentially introduced mutations into …
phenotypes of malignancy remains a challenge. We sequentially introduced mutations into …
MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment
S Riesenberg, A Groetchen, R Siddaway, T Bald… - Nature …, 2015 - nature.com
Inflammation promotes phenotypic plasticity in melanoma, a source of non-genetic
heterogeneity, but the molecular framework is poorly understood. Here we use functional …
heterogeneity, but the molecular framework is poorly understood. Here we use functional …
Pyroptosis-related gene signatures can robustly diagnose skin cutaneous melanoma and predict the prognosis
A Ju, J Tang, S Chen, Y Fu, Y Luo - Frontiers in oncology, 2021 - frontiersin.org
Skin cutaneous melanoma (SKCM) is a chronically malignant tumor with a high mortality
rate. Pyroptosis, a kind of pro-inflammatory programmed cell death, has been linked to …
rate. Pyroptosis, a kind of pro-inflammatory programmed cell death, has been linked to …
NF1‐mutated melanoma tumors harbor distinct clinical and biological characteristics
H Cirenajwis, M Lauss, H Ekedahl… - Molecular …, 2017 - Wiley Online Library
In general, melanoma can be considered as a UV‐driven disease with an aggressive
metastatic course and high mutational load, with only few tumors (acral, mucosal, and uveal …
metastatic course and high mutational load, with only few tumors (acral, mucosal, and uveal …