The emergence of antibiotic-resistant bacterial strains is a source of public health concern
across the globe. As the discovery of new conventional antibiotics has stalled significantly …

The clinical impact of infections due to extended-spectrum β-lactamase (ESBL)-and/or
carbapenemase-producing Enterobacterales (Ent) has reached dramatic levels worldwide …

Antibiotic treatments have detrimental effects on the microbiome and lead to antibiotic
resistance. To develop a phage therapy against a diverse range of clinically relevant …

Biomedical researchers have subsequently been inspired the development of new
approaches for precisely changing an organism's genomic DNA in order to investigate …

The emergence and global epidemic of antimicrobial resistance (AMR) poses a serious
threat to global public health in recent years. AMR genes are shared between bacterial …

CreTA, CRISPR-regulated toxin-antitoxin (TA), safeguards CRISPR-Cas immune systems by
inducing cell dormancy/death upon their inactivation. Here, we characterize a bacterial …

The use of biomaterials in delivering CRISPR/Cas9 for gene therapy in infectious diseases
holds tremendous potential. This innovative approach combines the advantages of …

The emergence and development of antibiotic resistance in bacteria is a serious threat to
global public health. Antibiotic resistance genes (ARGs) are often located on mobile genetic …

The development of precise and controlled CRISPR-Cas tools has been made possible by
the discovery of protein inhibitors of CRISPR-Cas systems, called anti-CRISPRs (Acrs). The …

Antimicrobial resistance (AMR) poses a significant threat to the health, social, environment,
and economic sectors on a global scale and requires serious attention to addressing this …