The gut microbiome and hypertension
A large body of evidence has emerged in the past decade supporting a role for the gut
microbiome in the regulation of blood pressure. The field has moved from association to …
microbiome in the regulation of blood pressure. The field has moved from association to …
[HTML][HTML] Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications
M Tomaszewski, AP Morris, JMM Howson… - Kidney international, 2022 - Elsevier
Hypertension is a major cardiovascular disease risk factor and contributor to premature
death globally. Family-based investigations confirmed a significant heritable component of …
death globally. Family-based investigations confirmed a significant heritable component of …
A wide range of missing imputation approaches in longitudinal data: a simulation study and real data analysis
Background Missing data is a pervasive problem in longitudinal data analysis. Several
single-imputation (SI) and multiple-imputation (MI) approaches have been proposed to …
single-imputation (SI) and multiple-imputation (MI) approaches have been proposed to …
Association of structural variation with cardiometabolic traits in Finns
The contribution of genome structural variation (SV) to quantitative traits associated with
cardiometabolic diseases remains largely unknown. Here, we present the results of a study …
cardiometabolic diseases remains largely unknown. Here, we present the results of a study …
[HTML][HTML] Familial aggregation of CKD and heritability of kidney biomarkers in the general population: the lifelines cohort study
J Zhang, CHL Thio, RT Gansevoort… - American Journal of Kidney …, 2021 - Elsevier
Rationale & Objective Chronic kidney disease (CKD) has a heritable component. We aimed
to quantify familial aggregation of CKD in the general population and assess the extent to …
to quantify familial aggregation of CKD in the general population and assess the extent to …
Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension
Genome-wide association studies of blood pressure (BP) have identified> 1,000 loci, but the
effector genes and biological pathways at these loci are mostly unknown. Using published …
effector genes and biological pathways at these loci are mostly unknown. Using published …
Gene-based association study reveals a distinct female genetic signal in primary hypertension
Hypertension is a polygenic disease that affects over 1.2 billion adults aged 30–79
worldwide. It is a major risk factor for renal, cerebrovascular, and cardiovascular diseases …
worldwide. It is a major risk factor for renal, cerebrovascular, and cardiovascular diseases …
Polygenic risk scores associate with blood pressure traits across the lifespan
K Øvretveit, EML Ingeström, M Spitieris… - European Journal of …, 2024 - academic.oup.com
Aims Hypertension is a major modifiable cause of morbidity and mortality that affects over 1
billion people worldwide. Blood pressure (BP) traits have a strong genetic component that …
billion people worldwide. Blood pressure (BP) traits have a strong genetic component that …
Genetically predicted blood pressure and cognition in midlife: A UK biobank study
BACKGROUND: This UK Biobank study uses a mendelian randomization approach to
mitigate the variability and confounding that has affected previous analyses of the …
mitigate the variability and confounding that has affected previous analyses of the …
Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits
Genome-wide association studies (GWAS) have identified thousands of genetic loci
associated with cross-sectional blood pressure (BP) traits; however, GWAS based on …
associated with cross-sectional blood pressure (BP) traits; however, GWAS based on …