Envelope-stress sensing mechanism of Rcs and Cpx signaling pathways in Gram-negative bacteria

SH Cho, K Dekoninck, JF Collet - Journal of Microbiology, 2023 - Springer
The global public health burden of bacterial antimicrobial resistance (AMR) is intensified by
Gram-negative bacteria, which have an additional membrane, the outer membrane (OM) …

BamE directly interacts with BamA and BamD coordinating their functions

S Kumar, A Konovalova - Molecular Microbiology, 2023 - Wiley Online Library
The β‐barrel assembly machinery (Bam) complex facilitates the assembly of outer
membrane proteins (OMPs) in gram‐negative bacteria. The Bam complex is conserved and …

Rcs signal transduction system in Escherichia coli: composition, related functions, regulatory mechanism, and applications

Z Li, Y Zhu, W Zhang, W Mu - Microbiological Research, 2024 - Elsevier
The regulator of capsule synthesis (Rcs) system, an atypical two-component system
prevalent in numerous gram-negative bacteria, serves as a sophisticated regulatory …

Molecular insights into the initiation step of the Rcs signaling pathway

N Watanabe, A Savchenko - Structure, 2024 - cell.com
The Rcs pathway is repressed by the inner membrane protein IgaA under non-stressed
conditions. This repression is hypothesized to be relieved by the binding of the outer …

RcsF-independent mechanisms of signaling within the Rcs Phosphorelay

A Petchiappan, N Majdalani, E Wall… - PLoS genetics, 2024 - journals.plos.org
The Rcs (regulator of capsule synthesis) phosphorelay is a conserved cell envelope stress
response mechanism in enterobacteria. It responds to perturbations at the cell surface and …

[HTML][HTML] The Role of Propionate-Induced Rearrangement of Membrane Proteins in the Formation of the Virulent Phenotype of Crohn's Disease-Associated Adherent …

OV Pobeguts, MA Galyamina, EV Mikhalchik… - International Journal of …, 2024 - mdpi.com
Adhesive-invasive E. coli has been suggested to be associated with the development of
Crohn's disease (CD). It is assumed that they can provoke the onset of the inflammatory …

Evolutionary analysis and structure modelling of the Rcs-repressor IgaA unveil a functional role of two cytoplasmic small β-barrel (SBB) domains

L Rodríguez, M Peñalver, P Casino… - Heliyon, 2023 - cell.com
The Rcs sensor system, comprising the RcsB/RcsC/RcsD and RcsF proteins, is used by
bacteria of the order Enterobacterales to withstand envelope damage. In non-stress …

Physiological and Transcriptomic Analyses of Escherichia coli Serotype O157:H7 in Response to Rhamnolipid Treatment

S Yang, L Ma, X Xu, Q Peng, H Zhong, Y Gong, L Shi… - Microorganisms, 2023 - mdpi.com
Rhamnolipid (RL) can inhibit biofilm formation of Escherichia coli O157: H7, but the
associated mechanism remains unknown. We here conducted comparative physiological …

Altering Escherichia coli envelope integrity by mimicking the lipoprotein RcsF

MA TagElDein, NG Mohamed, YE Shahein, L Ziko… - Archives of …, 2024 - Springer
Escherichia coli cell envelope is crucial for stress sensing and signal transduction, mediated
by numerous protein–protein interactions to enable adaptation and survival. Interfering with …

An Overview of Nanoparticle Properties and Their Bioactivity

CE Nwankwo, A Adewuyi, A Osho - International Journal of …, 2023 - go7publish.com
The term “nanoparticles” being expressed in microbiology is coined from the Greek word
“nano” meaning “dwarf”. Nanoparticles range in size from 1-100nm. Nanoparticles vary in …