Maintaining proteome integrity is essential for long-term viability of all organisms and is
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …

Misfolded, potentially toxic proteins in the lumen and membrane of the endoplasmic
reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated …

Protein folding is inherently error prone, especially in the endoplasmic reticulum (ER). Even
with an elaborate network of molecular chaperones and protein folding facilitators …

The endoplasmic reticulum (ER) is a large, dynamic, and multifunctional organelle. ER
protein homeostasis is essential for the coordination of its diverse functions and depends on …

Protein homeostasis mechanisms are fundamentally important to match cellular needs and
to counteract stress conditions. A fundamental challenge is to understand how defective …

The endoplasmic reticulum (ER) serves as a warehouse for factors that augment and control
the biogenesis of nascent proteins entering the secretory pathway. In turn, this compartment …

Numerous nascent proteins undergo folding and maturation within the luminal and
membrane compartments of the endoplasmic reticulum (ER). Despite the presence of …

Endoplasmic reticulum (ER)-associated degradation (ERAD) removes misfolded proteins
from the ER membrane and lumen by the ubiquitin-proteasome pathway. Retrotranslocation …

Protein quality control ensures the degradation of damaged and misfolded proteins.
Derangement of proteostasis is a primary cause of aging and age‐associated diseases. The …

The presenilins are the catalytic subunit of the membrane-embedded tetrameric γ-secretase
protease complexes. More that 90 transmembrane proteins have been reported to be γ …