[HTML][HTML] Role of prostaglandin E2 in tissue repair and regeneration

H Cheng, H Huang, Z Guo, Y Chang, Z Li - Theranostics, 2021 - ncbi.nlm.nih.gov
Tissue regeneration following injury from disease or medical treatment still represents a
challenge in regeneration medicine. Prostaglandin E2 (PGE2), which involves diverse …

[HTML][HTML] Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries

T Zhao, W Wu, L Sui, Q Huang, Y Nan, J Liu, K Ai - Bioactive Materials, 2022 - Elsevier
Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial
infarction, but morbidity and mortality of acute myocardial infarction are still high …

Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair

D Zhu, Z Li, K Huang, TG Caranasos, JS Rossi… - Nature …, 2021 - nature.com
Cardiac patches are an effective way to deliver therapeutics to the heart. However, such
procedures are normally invasive and difficult to perform. Here, we develop and test a …

Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies

M Liu, BL de Juan Abad, K Cheng - Advanced drug delivery reviews, 2021 - Elsevier
Cardiac fibrosis remains an unresolved problem in heart diseases. After initial injury, cardiac
fibroblasts (CFs) are activated and subsequently differentiate into myofibroblasts (myoFbs) …

Drug targeting via platelet membrane–coated nanoparticles

S Wang, Y Duan, Q Zhang, A Komarla, H Gong… - Small …, 2020 - Wiley Online Library
Platelets exhibit distinct surface moieties responsible for modulating their adhesion to
various disease‐relevant substrates involving vascular damage, immune evasion, and …

[HTML][HTML] Biomimetic platelet membrane-coated nanoparticles for targeted therapy

H Han, R Bartolo, J Li, MA Shahbazi… - European Journal of …, 2022 - Elsevier
The development of cell membrane-modified biomimetic nanoparticles has extensively
increased during the past years due to their exceptional biocompatibility, evasion from the …

A minimally invasive exosome spray repairs heart after myocardial infarction

J Yao, K Huang, D Zhu, T Chen, Y Jiang, J Zhang… - ACS …, 2021 - ACS Publications
Myocardial infarction (MI) remains the most common cause of death worldwide. Many MI
survivors will suffer from recurrent heart failure (HF), which has been recognized as a …

An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs

K Huang, EW Ozpinar, T Su, J Tang, D Shen… - Science translational …, 2020 - science.org
Cell therapy has been a promising strategy for cardiac repair after injury or infarction;
however, low retention and engraftment of transplanted cells limit potential therapeutic …

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

S Hu, X Wang, Z Li, D Zhu, J Cores, Z Wang, J Li, X Mei… - Nano today, 2021 - Elsevier
Exosomes from mesenchymal stem cells have been widely studied as therapeutics to treat
myocardial infarction. However, exosomes injected for therapeutic purposes face a number …

Platelet-armored nanoplatform to harmonize janus-faced IFN-γ against tumor recurrence and metastasis

Q Li, Y Zhou, W He, X Ren, M Zhang, Y Jiang… - Journal of Controlled …, 2021 - Elsevier
Abstract Interferon-γ (IFN-γ) plays contradictory roles in tumor immunology:(I) to activate
positive host's immunity for eliminating tumor;(II) to induce negative adaptive immune …