Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

To date, single-cell studies of human white adipose tissue (WAT) have been based on small
cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a …

Exercise training is critical for the prevention and treatment of obesity, but its underlying
mechanisms remain incompletely understood given the challenge of profiling …

Rather than serving as a mere onlooker, adipose tissue is a complex endocrine organ and
active participant in disease initiation and progression. Disruptions of biological processes …

Fibrosis disrupts adipose tissue (AT) homeostasis and exacerbates metabolic dysfunction
upon chronic caloric excess. The molecular mechanisms linking adipocyte plasticity to AT …

Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …

Healthy adipose tissue remodeling depends on the balance between de novo adipogenesis
from adipogenic progenitor cells and the hypertrophy of adipocytes. De novo adipogenesis …

Background As common progenitor cells of osteoblasts and adipocytes, bone marrow
mesenchymal (stromal) stem cells (BMSCs) play key roles in bone homeostasis, tissue …

Single-cell RNA sequencing (scRNA-seq) has revealed that adult white adipose tissue
(WAT) harbors functionally diverse subpopulations of mesenchymal stromal cells that …