Cardiopulmonary bypass (CPB) has allowed for significant surgical advancements, but
accompanying risks can be significant and must be expertly managed. One of the foremost …

Background Andexanet alfa is a modified recombinant inactive form of human factor Xa
developed for reversal of factor Xa inhibitors. Methods We evaluated 352 patients who had …

Purpose Although direct oral anticoagulants (DOACs) are associated with an overall
favourable safety profile, the risk of gastrointestinal bleeding with DOACs compared with …

Background Several clinical investigations have compared different pharmacologic agents
for the prophylaxis of venous thromboembolism (VTE). However, no consensus has been …

Abstract The World Health Organization estimates that the world's population over 60 years
of age will nearly double in the next 30 years. This change imposes increasing demands on …

Many clinicians increasingly use dry needling in clinical practice. However, whether patients'
intake of antithrombotic drugs should be considered as a contraindication for dry needling …

Introduction Cardiac patients on antiplatelets or oral anticoagulation undergoing emergent
cardiac surgery without appropriate washout periods are at increased risk for developing …

The indications of direct oral anticoagulants (DOACs) have expanded over the past 15
years. DOACs are effective and safe oral anticoagulants associated with lower bleeding …

OBJECTIVES Literature is scarce on the management of patients using direct oral
anticoagulants (DOACs) undergoing elective, urgent and emergency surgery. Therefore, we …

Objectives: Identify the indications of rivaroxaban therapy. Describe the mechanism of action
of rivaroxaban. Outline the contraindications in a patient on rivaroxaban therapy. Review the …