Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

In the panorama of inflammatory arthritis, gout is the most common and studied disease. It is
known that hyperuricemia and monosodium urate (MSU) crystal-induced inflammation …

Cisplatin (DDP) was reported to improve pathological complete response (pCR) rates in
triple-negative breast cancer (TNBC) patients, however, the molecular mechanism still …

The world has witnessed a high morbidity and mortality caused by SARS-CoV-2, and global
death toll is still rising. Exaggerated inflammatory responses are thought to be more …

ABSTRACT The NACHT, LRR and PYD domains-containing protein 3 (NLRP3)
inflammasome is a fascinating cellular machinery endowed with the capacity for rapid …

Fibrotic diseases cause annually more than 800,000 deaths worldwide, where of the
majority accounts for cardiovascular fibrosis, which is characterized by endothelial …

Diabetic nephropathy (DN), a sterile inflammatory disease, is a serious complication of
diabetes mellitus. However, recent evidence indicates that pyroptosis, a new term for pro …

Epidemiological research has shown that elevated serum urate concentration is a risk factor
for the development of kidney disease; however, the mechanisms underlying this process …

Pharmacologically inhibiting nucleotide-binding domain and leucine-rich repeat-containing
(NLR) family, pyrin domain–containing protein 3 (NLRP3) inflammasome activation results …

Aims Diabetic nephropathy (DN) is the most frequent complication of diabetes and causes
millions of deaths each year. Finding novel therapy to DN is urgent, which requires a good …