Small molecules that bind to normally unoccupied thyroxine (T4) binding sites within
transthyretin (TTR) in the blood stabilize the tetrameric ground state of TTR relative to the …

Transthyretin (TTR) is a homotetrameric serum and cerebrospinal fluid protein that
transports both thyroxine (T4) and the retinol-retinol binding protein complex (holoRBP) …

Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic
amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native …

Objective. Rate-limiting transthyretin (TTR) tetramer dissociation and monomer misfolding
enable misassembly into numerous aggregate morphologies including amyloid, a process …

Several natural polyphenols with potent inhibitory effects on amyloid fibril formation have
been reported. Herein, we studied modulation of transthyretin (TTR) fibrillogenesis by …

More than 100 transthyretin (TTR) variants are associated with hereditary amyloidosis.
Approaches for TTR amyloidosis that interfere with any step of the cascade of events leading …

Transthyretin (TTR), an homotetrameric protein mainly synthesized by the liver and the
choroid plexus, and secreted into the blood and the cerebrospinal fluid, respectively, has …

RNA interference (RNAi) is a naturally existing endogenous mechanism for post-
transcriptional gene regulation, nowadays commonly utilized for functional characterization …

Background Familial amyloidotic polyneuropathy (FAP) is a neurodegenerative disease
caused by the extracellular deposition of mutant transthyretin (TTR), with special …

Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressively debilitating, rare
disease associated with high mortality. ATTR-CM occurs when TTR amyloid protein builds …