Immunomodulatory action of Lactococcus lactis

LAK Saleena, MYM Teo, YH How, LLA In… - Journal of bioscience and …, 2023 - Elsevier
Highlights•Superior biological activities of different Lactococcus lactis strains.•Upregulation
of innate and specialised immune responses in all compartments.•Several potential health …

Freeze drying of food-grade recombinant Lactococcus lactis NZ3900-fermented milk with different protecting agents

YH How, MYM Teo, LLA In, SK Yeo, B Bhandari… - International Dairy …, 2023 - Elsevier
Lactococcus lactis NZ3900 expressing K-ras mimotope as a live vaccine is a promising non-
invasive form of targeted immunotherapy for K-ras-mutated colorectal cancers. However, the …

Nisin controlled homologous Over-expression of an exopolysaccharide biosynthetic glycosyltransferase gene for enhanced EPS production in Lactobacillus …

MP Soumya, R Parameswaran, KM Nampoothiri - Bioresource Technology, 2023 - Elsevier
Glycosyltransferases synthesize a variety of exopolysaccharides (EPS) with different
properties by altering the type of glycosidic linkage, degree of branching, length, mass, and …

[HTML][HTML] Development of fermented milk using food-grade recombinant Lactococcus lactis NZ3900

YH How, MYM Teo, LLA In, SK Yeo, LP Pui - NFS Journal, 2022 - Elsevier
Fermented milk has been associated with the improvement of human health for decades.
Food-grade Lactococcus lactis NZ3900 is a potential host for producing and delivering …

[HTML][HTML] Adenovirus-mediated expression of MOAP-1, Bax and RASSF1A antagonizes chemo-drug resistance of human breast cancer cells expressing cancer stem …

EW Tan, ADI Abdullah, LC Ming, CL Poh… - Biomedicine & …, 2024 - Elsevier
Cancer is one of the major leading causes of mortality globally and chemo-drug-resistant
cancers pose significant challenges to cancer treatment by reducing patient survival rates …

Stability and expression of K-ras mimotopes in freeze-dried recombinant Lactococcus lactis NZ3900-fermented milk powder during storage in vacuum packaging

YH How, MYM Teo, LLA In, SK Yeo… - Journal of Applied …, 2024 - academic.oup.com
Aims This study aims to evaluate the storage stability of the freeze-dried recombinant
Lactococcus lactis NZ3900-fermented milk powder expressing K-ras (Kristen rat sarcoma …

[HTML][HTML] K-Ras peptide mimotope induces antigen specific Th1 and B-cell immune responses against G12A-mutated K-Ras antigen in balb/c mice

PY Siak, KY Wong, AAL Song, RA Rahim, LLA In - Vaccines, 2021 - mdpi.com
KRAS G12A somatic point mutation in adenocarcinomas is categorized clinically as
ineligibility criteria for anti-epidermal growth factor receptor (EGFR) monoclonal antibody …

[HTML][HTML] Effect of Secretion Efficiency of Mutant KRAS Neoantigen by Lactococcus lactis on the Immune Response of a Mucosal Vaccine Delivery Vehicle Targeting …

NAR Alias, WPY Hoo, PY Siak, SS Othman… - International Journal of …, 2023 - mdpi.com
Colorectal cancer (CRC) is often caused by mutations in the KRAS oncogene, making KRAS
neoantigens a promising vaccine candidate for immunotherapy. Secreting KRAS antigens …

Storage stability of food-grade recombinant Lactococcus lactis NZ3900-fermented milk expressing K-ras mimotopes

YH How, MYM Teo, LLA In, SK Yeo, B Bhandari… - Journal of Food …, 2024 - Springer
K-ras mimotope expressed by Lactococcus lactis NZ3900 is a potential live oral vaccine
developed to target specific K-ras mutations in colorectal cancer. However, the storage and …