Protective or detrimental? understanding the role of host immunity in leishmaniasis
C dos Santos Meira, L Gedamu - Microorganisms, 2019 - mdpi.com
The intracellular protozoan parasites of the genus Leishmania are the causative agents of
leishmaniasis, a vector-borne disease of major public health concern, estimated to affect 12 …
leishmaniasis, a vector-borne disease of major public health concern, estimated to affect 12 …
Leishmania vaccine development: A comprehensive review
Infectious diseases like leishmaniasis, malaria, HIV, tuberculosis, leprosy and filariasis are
responsible for an immense burden on public health systems. Among these, leishmaniasis …
responsible for an immense burden on public health systems. Among these, leishmaniasis …
A recombinant Leishmania amastigote-specific protein, rLiHyG, with adjuvants, protects against infection with Leishmania infantum
AS Machado, DP Lage, DL Vale, CS Freitas… - Acta Tropica, 2022 - Elsevier
Vaccination against visceral leishmaniasis (VL) should be considered as a control measure
to protect against disease, and amastigote-specific proteins could help to develop such …
to protect against disease, and amastigote-specific proteins could help to develop such …
Epitope-binding characteristics for risk versus protective DRB1 alleles for visceral leishmaniasis
HLA-DRB1 is the major genetic risk factor for visceral leishmaniasis (VL). We used
SNP2HLA to impute HLA-DRB1 alleles and SNPTEST to carry out association analyses in …
SNP2HLA to impute HLA-DRB1 alleles and SNPTEST to carry out association analyses in …
Efficacy of an Immunotherapy Combining Immunogenic Chimeric Protein Plus Adjuvant and Amphotericin B against Murine Visceral Leishmaniasis
DL Vale, CS Freitas, VT Martins, GJL Moreira… - Biology, 2023 - mdpi.com
Simple Summary Visceral leishmaniasis is a tropical neglected disease caused by infection
with Leishmania parasites. There are no human vaccines and the current drug treatments for …
with Leishmania parasites. There are no human vaccines and the current drug treatments for …
Leishmania infantum pyridoxal kinase evaluated in a recombinant protein and DNA vaccine to protects against visceral leishmaniasis
JA Oliveira-da-Silva, DP Lage, FF Ramos… - Molecular …, 2020 - Elsevier
Leishmania infantum pyridoxal kinase (PK) protein was characterized after an
immunoproteomics screening performed with the sera from patients suffering visceral …
immunoproteomics screening performed with the sera from patients suffering visceral …
Recombinant small glutamine-rich tetratricopeptide repeat-containing protein of Leishmania infantum: Potential vaccine and diagnostic application against visceral …
DS Dias, PAF Ribeiro, VT Martins, DP Lage… - Molecular …, 2017 - Elsevier
Different Leishmania proteins have been evaluated in order to find a potential vaccine
candidate or diagnostic marker capable of providing long lasting protection against infection …
candidate or diagnostic marker capable of providing long lasting protection against infection …
A Leishmania amastigote-specific hypothetical protein evaluated as recombinant protein plus Th1 adjuvant or DNA plasmid-based vaccine to protect against visceral …
JA Oliveira-da-Silva, AS Machado, FF Ramos… - Cellular …, 2020 - Elsevier
Most studies evaluating vaccine candidates against visceral leishmaniasis (VL) have used
parasite promastigote-expressed antigens; however, Leishmania proteins expressed in the …
parasite promastigote-expressed antigens; however, Leishmania proteins expressed in the …
Evaluation of a Leishmania hypothetical protein administered as DNA vaccine or recombinant protein against Leishmania infantum infection and its immunogenicity in …
Visceral leishmaniasis (VL) is a fatal disease when acute and untreated. The treatment
against this disease is long and presents toxicity and/or high costs. Moreover, parasite …
against this disease is long and presents toxicity and/or high costs. Moreover, parasite …
Analysis of the Antigenic and Prophylactic Properties of the Leishmania Translation Initiation Factors eIF2 and eIF2B in Natural and Experimental Leishmaniasis
Different members of intracellular protein families are recognized by the immune system of
the vertebrate host infected by parasites of the genus Leishmania. Here, we have analyzed …
the vertebrate host infected by parasites of the genus Leishmania. Here, we have analyzed …