The relevance of potentially reversible post-translational modifications required for
controlling cellular processes in cancer is one of the most thriving arenas of cellular and …

Shp1 is a cytosolic tyrosine phosphatase that regulates a broad range of cellular functions
and targets, modulating the flow of information from the cell membrane to the nucleus. While …

Cell synchronization is widely used in studying mechanisms involves in regulation of cell
cycle progression. Through synchronization, cells at distinct cell cycle stage could be …

Preclinical models have been the workhorse of cancer research, producing massive
amounts of drug response data. Unfortunately, translating response biomarkers derived from …

Photobiomodulation (PBM) is a noninvasive photonic-based therapy, capable of dealing
with immune-inflammatory, neurological, and musculoskeletal disorders, as well as healing …

Protein tyrosine kinases, especially receptor tyrosine kinases, have dominated the cancer
therapeutics sphere as proteins that can be inhibited to selectively target cancer. However …

Increased proliferation after low-level laser irradiation (LLLI) has been well demonstrated in
many cell types including mesenchymal stem cells (MSCs), but the exact molecular …

The nuclear receptor (NR) superfamily consists of 48 members that are divided into seven
subfamilies. NRs are transcription factors that play an important role in a number of …

Sorafenib is the first approved targeted therapeutic reagent for hepatocellular carcinoma
(HCC). Here, we report that Src homology region 2 (SH2) domain-containing phosphatase 1 …

Tyrosine phosphorylation of proteins serves as an exquisite switch in controlling several key
oncogenic signaling pathways involved in cell proliferation, apoptosis, migration, and …