Human topoisomerases and their roles in genome stability and organization
Y Pommier, A Nussenzweig, S Takeda… - … Reviews Molecular Cell …, 2022 - nature.com
Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
Cellular functions of the protein kinase ATM and their relevance to human disease
The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
[HTML][HTML] R loops: from physiological to pathological roles
T García-Muse, A Aguilera - Cell, 2019 - cell.com
DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent
non-scheduled co-transcriptional structures with a negative impact on transcription …
non-scheduled co-transcriptional structures with a negative impact on transcription …
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
The DNA damage response to transcription stress
The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …
Ataxia telangiectasia: a review
C Rothblum-Oviatt, J Wright, MA Lefton-Greif… - Orphanet journal of rare …, 2016 - Springer
Definition of the disease Ataxia telangiectasia (AT) is an autosomal recessive disorder
primarily characterized by cerebellar degeneration, telangiectasia, immunodeficiency …
primarily characterized by cerebellar degeneration, telangiectasia, immunodeficiency …
RNA/DNA hybrid interactome identifies DXH9 as a molecular player in transcriptional termination and R-loop-associated DNA damage
R-loops comprise an RNA/DNA hybrid and displaced single-stranded DNA. They play
important biological roles and are implicated in pathology. Even so, proteins recognizing …
important biological roles and are implicated in pathology. Even so, proteins recognizing …
Genome organization drives chromosome fragility
In this study, we show that evolutionarily conserved chromosome loop anchors bound by
CCCTC-binding factor (CTCF) and cohesin are vulnerable to DNA double strand breaks …
CCCTC-binding factor (CTCF) and cohesin are vulnerable to DNA double strand breaks …
Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability
J Sollier, CT Stork, ML García-Rubio, RD Paulsen… - Molecular cell, 2014 - cell.com
R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are
physiological structures that regulate various cellular processes occurring on chromatin …
physiological structures that regulate various cellular processes occurring on chromatin …
R loops: from transcription byproducts to threats to genome stability
A Aguilera, T García-Muse - Molecular cell, 2012 - cell.com
RNA: DNA hybrid structures known as R loops were thought to be rare byproducts of
transcription. In the last decade, however, accumulating evidence has pointed to a new view …
transcription. In the last decade, however, accumulating evidence has pointed to a new view …