Tipping the balance: intricate roles of the complement system in disease and therapy
The ability of the complement system to rapidly and broadly react to microbial intruders,
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …
Mimicking the natural basement membrane for advanced tissue engineering
Advancements in the field of tissue engineering have led to the elucidation of physical and
chemical characteristics of physiological basement membranes (BM) as specialized forms of …
chemical characteristics of physiological basement membranes (BM) as specialized forms of …
The anaphylatoxin C5a: Structure, function, signaling, physiology, disease, and therapeutics
The complement system is one of the oldest known tightly regulated host defense systems
evolved for efficiently functioning cell-based immune systems and antibodies. Essentially …
evolved for efficiently functioning cell-based immune systems and antibodies. Essentially …
Combined treatment of xyloglucan derivative hydrogel and anti-C5a receptor antibody in preventing peritoneal adhesion
Postoperative peritoneal adhesion is a common complication after surgery with high
morbidity. In addition to improving surgical operations, medical therapy and physical barriers …
morbidity. In addition to improving surgical operations, medical therapy and physical barriers …
[HTML][HTML] Pulmonary manifestations and vascular changes in pediatric transplantation-associated thrombotic microangiopathy
ML Schoettler, BD Saldana, L Berkenkamp… - … and cellular therapy, 2023 - Elsevier
Although transplant-associated thrombotic microangiopathy (TA-TMA) commonly
complicates pediatric hematopoietic cellular therapy (HCT), pulmonary manifestations and …
complicates pediatric hematopoietic cellular therapy (HCT), pulmonary manifestations and …
C5a drives the inflammatory response with bacterial dose effect by binding to C5aR1 in zebrafish infected with Aeromonas hydrophila
The complement system is essential to host defense, but its excessive activation caused by
severe pathogen invasion is a driving force in adverse inflammatory. The binding of …
severe pathogen invasion is a driving force in adverse inflammatory. The binding of …
Silenced-C5ar1 improved multiple organ injury in sepsis rats via inhibiting neutrophil extracellular trap
B Shen, Q Shen, Q Zeng, L Zhang, X Li - Journal of Molecular Histology, 2024 - Springer
Sepsis has a systemic inflammatory response syndrome caused by infection. While
neutrophils play contradictory roles in different stages of sepsis. Neutrophils have been …
neutrophils play contradictory roles in different stages of sepsis. Neutrophils have been …
Crepuscular rays—The bright side of complement after tissue injury
M Mannes, S Savukoski, A Ignatius… - European Journal of …, 2024 - Wiley Online Library
Acute injuries trigger an intense activation of the body's defense mechanisms aiming to limit
damage and initiate healing. Among the crucial components of the intravascular immune …
damage and initiate healing. Among the crucial components of the intravascular immune …
[HTML][HTML] Pro-inflammatory regulatory mechanism of C5a/C5aR pathway in GCRV-infected grass carp (Ctenopharyngodon idella)
B Xu, H Su, C Chen, Q Liu, T Xiao, Y Liu, Z Lv… - Aquaculture …, 2023 - Elsevier
Death of grass carp (Ctenopharyngodon idella) caused by grass carp reovirus (GCRV)
infection severely restricts the development of the grass carp industry. The interaction of C5a …
infection severely restricts the development of the grass carp industry. The interaction of C5a …
Advances in Therapeutic L-Nucleosides and L-Nucleic Acids with Unusual Handedness
Y Dantsu, Y Zhang, W Zhang - Genes, 2021 - mdpi.com
Nucleic-acid-based small molecule and oligonucleotide therapies are attractive topics due
to their potential for effective target of disease-related modules and specific control of …
to their potential for effective target of disease-related modules and specific control of …