Tipping the balance: intricate roles of the complement system in disease and therapy

RB Pouw, D Ricklin - Seminars in Immunopathology, 2021 - Springer
The ability of the complement system to rapidly and broadly react to microbial intruders,
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …

Mimicking the natural basement membrane for advanced tissue engineering

P Jain, SB Rauer, M Möller, S Singh - Biomacromolecules, 2022 - ACS Publications
Advancements in the field of tissue engineering have led to the elucidation of physical and
chemical characteristics of physiological basement membranes (BM) as specialized forms of …

The anaphylatoxin C5a: Structure, function, signaling, physiology, disease, and therapeutics

M Ghosh, S Rana - International Immunopharmacology, 2023 - Elsevier
The complement system is one of the oldest known tightly regulated host defense systems
evolved for efficiently functioning cell-based immune systems and antibodies. Essentially …

Combined treatment of xyloglucan derivative hydrogel and anti-C5a receptor antibody in preventing peritoneal adhesion

L Jiang, F Yao, E Zhang, Q Yu, C Yu, Z Chen, J Chen… - Acta Biomaterialia, 2022 - Elsevier
Postoperative peritoneal adhesion is a common complication after surgery with high
morbidity. In addition to improving surgical operations, medical therapy and physical barriers …

[HTML][HTML] Pulmonary manifestations and vascular changes in pediatric transplantation-associated thrombotic microangiopathy

ML Schoettler, BD Saldana, L Berkenkamp… - … and cellular therapy, 2023 - Elsevier
Although transplant-associated thrombotic microangiopathy (TA-TMA) commonly
complicates pediatric hematopoietic cellular therapy (HCT), pulmonary manifestations and …

C5a drives the inflammatory response with bacterial dose effect by binding to C5aR1 in zebrafish infected with Aeromonas hydrophila

X Liu, W Wang, S Tan, H Liu, Z Li, N Wang, J Ma… - Fish & Shellfish …, 2023 - Elsevier
The complement system is essential to host defense, but its excessive activation caused by
severe pathogen invasion is a driving force in adverse inflammatory. The binding of …

Silenced-C5ar1 improved multiple organ injury in sepsis rats via inhibiting neutrophil extracellular trap

B Shen, Q Shen, Q Zeng, L Zhang, X Li - Journal of Molecular Histology, 2024 - Springer
Sepsis has a systemic inflammatory response syndrome caused by infection. While
neutrophils play contradictory roles in different stages of sepsis. Neutrophils have been …

Crepuscular rays—The bright side of complement after tissue injury

M Mannes, S Savukoski, A Ignatius… - European Journal of …, 2024 - Wiley Online Library
Acute injuries trigger an intense activation of the body's defense mechanisms aiming to limit
damage and initiate healing. Among the crucial components of the intravascular immune …

[HTML][HTML] Pro-inflammatory regulatory mechanism of C5a/C5aR pathway in GCRV-infected grass carp (Ctenopharyngodon idella)

B Xu, H Su, C Chen, Q Liu, T Xiao, Y Liu, Z Lv… - Aquaculture …, 2023 - Elsevier
Death of grass carp (Ctenopharyngodon idella) caused by grass carp reovirus (GCRV)
infection severely restricts the development of the grass carp industry. The interaction of C5a …

Advances in Therapeutic L-Nucleosides and L-Nucleic Acids with Unusual Handedness

Y Dantsu, Y Zhang, W Zhang - Genes, 2021 - mdpi.com
Nucleic-acid-based small molecule and oligonucleotide therapies are attractive topics due
to their potential for effective target of disease-related modules and specific control of …