Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key
cellular functions including proliferation, differentiation, migration, genetic stability …

β‐Catenin (Armadillo in Drosophila) is a multitasking and evolutionary conserved molecule
that in metazoans exerts a crucial role in a multitude of developmental and homeostatic …

T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end
point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are …

Myelin sheaths provide critical functional and trophic support for axons in white matter tracts
of the brain. Oligodendrocyte precursor cells (OPCs) have extraordinary metabolic …

Mutations in the adenomatous polyposis coli (APC) tumour-suppressor gene occur in most
human colon cancers. Loss of functional APC protein results in the accumulation of β …

Wnt regulation of β-catenin degradation is essential for development and carcinogenesis. β-
catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation …

The adenomatous polyposis coli (APC) tumor suppressor protein binds to β-catenin, a
protein recently shown to interact with Tcf and Lef transcription factors. The gene encoding …

The canonical Wnt/β-catenin signaling pathway, an important modulator of progenitor cell
proliferation and differentiation, is highly regulated for the maintenance of critical biological …

The regulation of cell growth and survival can be subverted by a variety of genetic defects
that alter transcriptional programs normally responsible for controlling cell number. High …