Peptides and proteins are naturally chiral molecular systems so that sensing their structure
and conformation with chirality-based spectral methods is an obvious and long-used …

There is an enormous amount of interest in the structures and formation mechanisms of
amyloid fibers. In this Perspective, we review the most common structural motifs of amyloid …

Vibrational optical activity (VOA) refers to two vibrational techniques: vibrational circular
dichroism (VCD) and Raman optical activity (ROA) that are sensitive both to the chirality and …

This book details chiroptical spectroscopic methods: electronic circular dichroism (ECD),
optical rotatory dispersion (ORD), vibrational circular dichroism (VCD), and vibrational …

Amyloid diseases, including neurodegenerative diseases such as Alzheimer's and
Parkinson's, are linked to a poorly understood progression of protein misfolding and …

Cyclic peptides are a promising class of compounds for next-generation antibiotics as they
may provide new ways of limiting antibiotic resistance development. Although their cyclic …

Transiently populated oligomers formed en route to amyloid fibrils may constitute the most
toxic aggregates associated with many amyloid-associated diseases. Most nucleation …

Amyloid fibrils are supramolecular systems showing distinct chirality at different levels of
their complex multilayered architectures. Due to the regular long‐range chiral organization …

The analysis and interpretation of the vibrational spectra of complex (bio) molecular
systems, such as polypeptides and proteins, requires support from quantum‐chemical …

While the intensity of vibrational circular dichroism (VCD) signals is commonly 104–105
times smaller than that of corresponding IR signals, several kinds of systems display …