Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …

Glioma is the most aggressive and malignant type of primary brain tumor, comprises the
majority of central nervous system deaths, and is categorized into different subgroups …

As the use of zinc oxide nanoparticles (ZnO NPs) in everyday products grows, so does
concern about health risks. However, no findings on the gastrointestinal toxicity of ZnO NPs …

Abstract The Cdc2-like kinases (CLKs 1–4) are involved in regulating the alternative splicing
of a variety of genes. Their activity contributes to important cellular processes such as …

Abstract The CLKs (Cdc2-like kinases) belong to the dual-specificity protein kinase family
and play crucial roles in regulating transcript splicing via the phosphorylation of SR proteins …

Ethnopharmacological relevance Xihuang pill has been utilized to treat cancer for more than
three hundred years in China. The molecular mechanisms of Xihuang pill in treating …

Temozolomide (TMZ) is a chemotherapeutic agent that has been the first-line standard of
care for the aggressive brain cancer glioblastoma (GBM) since 2005. Although initially …

Background: Even with decades of intensive study, the signaling regulative network of the
progression of Glioblastoma (GBM) remains unclear, a deeper understanding of the …

Transcription factor NF-κB potently activates anti-apoptotic genes, and its inactivation
significantly reduces tumor cell survival following genotoxic stresses. We identified two …

Background: Even with decades of intensive study, the signaling regulative network of the
progression of GBM remains unclear, a deeper understanding of the molecular crosstalk …