The zebrafish has become a prominent vertebrate model for disease and has already
contributed to several examples of successful phenotype-based drug discovery. For the …

The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Aquatic environments are often contaminated with complex mixtures of chemicals that may
pose a risk to ecosystems and human health. This contamination cannot be addressed with …

Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to
the phylum Osteichthyes, from which their endoskeletal systems have been inherited …

Glucocorticoids are steroid hormones of the adrenal gland that are an integral component of
the stress response and regulate many physiological processes, including metabolism and …

Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation
of biological processes. Compound toxicities, chemical alterations by metabolism …

Glucocorticoids serve important regulatory functions for many physiological processes and
are critical mediators of the stress response. The stress response is a set of bodily processes …

Recent findings indicate that different Endocrine Disrupting Chemicals (EDCs) interfere with
lipid metabolic pathways in mammals and promote fat accumulation, a previously unknown …

Obesity and its related disorders are the most prevalent health problems in the Western
world. Using the paradigm of fetal programming we developed a rodent model which …

The growing number of manufactured nanomaterials (MNMs) used in consumer products
and industrial applications is leading to increased exposures whose consequences are not …