The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

tRNA biology has come of age, revealing an unprecedented level of understanding and
many unexpected discoveries along the way. This review highlights new findings on the …

The ribosome, the largest RNA-containing macromolecular machinery in cells, requires
metal ions not only to maintain its three-dimensional fold but also to perform protein …

Methylation of RNA occurs at a variety of atoms, nucleotides, sequences and tertiary
structures. Strongly related to other posttranscriptional modifications, methylation of different …

Following synthesis, tRNAs are peppered by numerous chemical modifications which may
differentially affect a tRNA's structure and function. Although modifications affecting the …

The genetic code is degenerate, in that 20 amino acids are encoded by 61 triplet codes. In
1966, Francis Crick hypothesized that the cell's limited number of tRNAs decoded the …

One key question in protein biosynthesis is how the ribosome couples mRNA and tRNA
movements to prevent disruption of weak codon-anticodon interactions and loss of the …

Transfer RNA's role in decoding the genome is critical to the accuracy and efficiency of
protein synthesis. Though modified nucleosides were identified in RNA 50 years ago, only …

To date, more than 90 modified nucleosides have been found in tRNA and the biosynthetic
pathways of the majority of tRNA modifications include a methylation step (s). Recent studies …

Nature combines existing biochemical building blocks, at times with subtlety of purpose.
RNA modifications are a prime example of this, where standard RNA nucleosides are …