Autophagy controls cellular remodeling and quality control. Dysregulated autophagy has
been implicated in several human diseases including obesity, diabetes, cardiovascular …

Metal ions play an important role in biological processes and in metal homeostasis. Metal
imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer's …

Increased glucose production and reduced hepatic glycogen storage contribute to metabolic
abnormalities in diabetes. Irisin, a newly identified myokine, induces the browning of white …

We performed silencing and overexpression studies of flavin containing monooxygenase
(FMO) 3 in hyperlipidemic mouse models to examine its effects on trimethylamine N-oxide …

The manner in which insulin resistance impinges on hepatic mitochondrial function is
complex. Although liver insulin resistance is associated with respiratory dysfunction, the …

Adropin is a secreted peptide that improves hepatic steatosis and glucose homeostasis
when administered to diet‐induced obese mice. It is not clear if adropin is a peptide …

Type 2 diabetes is characterized by insulin resistance in target tissues and hyperglycemia.
Catalpol is a natural product isolated from the root of Rehmannia glutinosa, which has been …

Considerable data support the idea that forkhead box O1 (Foxo1) drives the liver
transcriptional program during fasting and is then inhibited by thymoma viral proto …

Given the functional importance of the endoplasmic reticulum (ER), an organelle that
performs folding, modification, and trafficking of secretory and membrane proteins to the …

Background: Type 2 diabetes is a growing public health problem and is associated with
increased morbidity and mortality. The worldwide prevalence of type 2 diabetes is rising …