Adsorption process has been widely used for treatment of wastewaters due to its simplicity
and lower costs as compared to other traditional technologies. Among the alternative …

Although idiosyncratic adverse drug reactions are rare, they are still a major concern to
patient safety. Reactive metabolites are widely accepted as playing a pivotal role in the …

Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family mainly targeting
cytosolic nonhistone substrates, such as α-tubulin, cortactin, and heat shock protein 90 to …

Lead optimization represents the tedious process of fine‐tuning lead compounds from
biologically active hits to suitable drug candidates for clinical trials. By chemically modifying …

Emerging contaminants, as a group of trace contaminants arising from pharmaceuticals,
personal care products, etc., are of growing concern due to their potential hazard to the …

Abstract TAK-875, a GPR40 agonist, was withdrawn from Phase III clinical trials due to drug-
induced liver injury (DILI). Mechanistic studies were conducted to identify potential DILI …

Lysine lactoylation is a recently described protein post-translational modification (PTM).
However, the biochemical pathways responsible for this acylation remain unclear. Two …

The aim of this study was to investigate whether thymoquinone (TQ) could alleviate
diclofenac (DCLF)-induced gastrointestinal and renal toxicity in rats. Diclofenac was …

By near-infrared (NIR) spectroscopy and anharmonic density functional theory (DFT)
calculations, we investigate five kinds of saturated and unsaturated carboxylic acids …

Acyl glucuronides are important metabolites of compounds with carboxylic acid moieties and
have unique properties that distinguish them from other phase 2 metabolites. In particular, in …