The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Activating mutations in the FGFR3 receptor tyrosine kinase lead to most prevalent form of
genetic dwarfism in humans, the achondroplasia. Many features of the complex function of …

Receptor guanylyl cyclases (GCs) are single membrane spanning, multidomain enzymes,
that synthesize cGMP in response to natriuretic peptides or other ligands. They are …

In response to luteinizing hormone (LH), multiple proteins in rat and mouse granulosa cells
are rapidly dephosphorylated, but the responsible phosphatases remain to be identified …

Atrial natriuretic peptide (NP) and BNP increase cGMP, which reduces blood pressure and
cardiac hypertrophy by activating guanylyl cyclase (GC)-A, also known as NPR-A or Npr1 …

Activating mutations in fibroblast growth factor receptor 3 (FGFR3) and inactivating
mutations in the natriuretic peptide receptor 2 (NPR2) guanylyl cyclase both result in …

The natriuretic peptide receptors NPR1 and NPR2, also known as guanylyl cyclase A and
guanylyl cyclase B, have critical functions in many signaling pathways, but much remains …

C-type natriuretic peptide (CNP) activation of guanylyl cyclase-B (GC-B) catalyzes the
synthesis of cGMP in chondrocytes and osteoblasts. Elevated cGMP stimulates long bone …

Acromesomelic dysplasia, Maroteaux type (AMDM) is a rare skeletal dysplasia
characterized by severe disproportionate short stature, short hands and feet, normal …

Increasing cGMP is a unique therapeutic principle, and drugs inhibiting cGMP-degrading
enzymes or stimulating cGMP production are approved for the treatment of various diseases …