Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives

RC Dutra, MM Campos, ARS Santos… - Pharmacological research, 2016 - Elsevier
This review article focuses on pre-clinical and clinical studies with some selected Brazilian
medicinal plants in different areas of interest, conducted by research groups in Brazil and …

Medicinal plants with inhibitory properties against snake venoms

AM Soares, FK Ticli, S Marcussi… - Current Medicinal …, 2005 - ingentaconnect.com
Envenomations due to snake bites are commonly treated by parenteral administration of
horse or sheep-derived polyclonal antivenoms aimed at the neutralization of toxins …

Medicinal plants for the treatment of local tissue damage induced by snake venoms: an overview from traditional use to pharmacological evidence

J Félix-Silva, AA Silva-Junior… - Evidence‐Based …, 2017 - Wiley Online Library
Snakebites are a serious problem in public health due to their high morbimortality. Most of
snake venoms produce intense local tissue damage, which could lead to temporary or …

Rosmarinic acid, a new snake venom phospholipase A2 inhibitor from Cordia verbenacea (Boraginaceae): antiserum action potentiation and molecular interaction

FK Ticli, LIS Hage, RS Cambraia, PS Pereira, ÂJ Magro… - Toxicon, 2005 - Elsevier
Many plants are used in traditional medicine as active agents against various effects
induced by snakebite. The methanolic extract from Cordia verbenacea (Cv) significantly …

The anti‐snake venom properties of Tamarindus indica (leguminosae) seed extract

S Ushanandini, S Nagaraju… - … Journal Devoted to …, 2006 - Wiley Online Library
In Indian traditional medicine, various plants have been used widely as a remedy for treating
snakebites. The aim of this study was to evaluate the effect of Tamarindus indica seed …

Snake Venom PLA2s Inhibitors Isolated from Brazilian Plants: Synthetic and Natural Molecules

BMA Carvalho, JDL Santos, BM Xavier… - BioMed Research …, 2013 - Wiley Online Library
Ophidian envenomation is an important health problem in Brazil and other South American
countries. In folk medicine, especially in developing countries, several vegetal species are …

Chemical modifications of phospholipases A2 from snake venoms: effects on catalytic and pharmacological properties

AM Soares, JR Giglio - Toxicon, 2003 - Elsevier
Phospholipases A2 (PLA2s) constitute major components of snake venoms and have been
extensively investigated not only because they are very abundant in these venoms but …

Neo-clerodane diterpenoid, a new metalloprotease snake venom inhibitor from Baccharis trimera (Asteraceae): anti-proteolytic and anti-hemorrhagic properties

AH Januário, SL Santos, S Marcussi, MV Mazzi… - Chemico-biological …, 2004 - Elsevier
Many plants are used in traditional medicine as active agents against various effects
induced by snakebite. Few attempts have been made however to identify the nature of plant …

Anticoagulant and antifibrinogenolytic properties of the aqueous extract from Bauhinia forficata against snake venoms

CZ Oliveira, VA Maiorano, S Marcussi… - Journal of …, 2005 - Elsevier
The aqueous extract from aerial parts of Bauhinia forficata was able to neutralize the clotting
activity induced by Bothrops and Crotalus crude venoms. The clotting time, upon human …

Snake venom phospholipase A2 inhibitors: medicinal chemistry and therapeutic potential

S Marcussi, CD Sant'Ana, CZ Oliveira… - Current topics in …, 2007 - ingentaconnect.com
Phospholipases A2 (PLA2s) are commonly found in snake venoms from Viperidae,
Hydrophidae and Elaphidae families and have been extensively studied due to their …