Polycystic ovary syndrome (PCOS) is increasingly recognized as a complex metabolic
disorder that manifests in genetically susceptible women following a range of negative …

GPR81 is a G-protein coupled receptor (GPCR) discovered in 2001, but deorphanized only
7 years later, when its affinity for lactate as an endogenous ligand was demonstrated. More …

Lineage plasticity is implicated in treatment resistance in multiple cancers. In lung
adenocarcinomas (LUAD) amenable to targeted therapy, transformation to small cell lung …

Human sleep phenotypes can be defined and diversified by both genetic and environmental
factors. However, some sleep phenotypes are difficult to evaluate without long-term, precise …

Background Lineage plasticity, the ability to transdifferentiate among distinct phenotypic
identities, facilitates therapeutic resistance in cancer. In lung adenocarcinomas (LUADs) …

The high‐throughput sequencing of cellular RNAs has underscored a broad effect of isoform
diversification through alternative splicing on the transcriptome. Moreover, the differential …

Objective Identification of genetic risk factors for Parkinson disease (PD) has to date been
primarily limited to the study of single nucleotide variants, which only represent a small …

Lung cancer has been identified as one of the most prevalent and deadly tumors worldwide.
In recent years, lncRNAs have been demonstrated to play a significant role in the …

Over the last decade, the increasing interest in long non-coding RNAs (lncRNAs) has led to
the discovery of these transcripts in multiple organisms. LncRNAs tend to be specifically …

In many species the mutation rate is higher in males than in females, a phenomenon
denoted as male mutation bias. This is often observed in animals where males produce …