[HTML][HTML] A mini-review of traditional Chinese medicines on liver diseases

SK Law, DCT Au, AWN Leung, C Xu - Pharmacological Research-Modern …, 2023 - Elsevier
Introduction Currently, around 2 million deaths per year are attributed to liver disorders
worldwide. There are many traditional Chinese medicines (TCM) and natural products used …

RNA-Seq analysis offers insight into the TBBPA-DHEE-induced endocrine-disrupting effect and neurotoxicity in juvenile zebrafish (Danio rerio)

ES Okeke, W Feng, M Luo, G Mao, Y Chen… - General and …, 2024 - Elsevier
Abstract Tetrabromobisphenol A bis (2-hydroxyethyl) ether (TBBPA-DHEE) is the major
TBBPA derivative. It has been detected in different environmental samples. Previous studies …

Fucoidan/hyaluronic acid cross-linked zein nanoparticles loaded with fisetin as a novel targeted nanotherapy for oral cancer

MA Moustafa, WM El-Refaie, YSR Elnaggar… - International Journal of …, 2023 - Elsevier
Fisetin (FS) is an anticancer drug having potential role in oral tumors management.
However, its clinical application is limited due to its hydrophobicity and instability. Bioactive …

Novel celecoxib-loaded chitosan-fucoidan nanoparticles as potential immunotherapy for oral squamous cell carcinoma: Mechanistic insights

AA Mabrouk, NS El-Mezayen, AK Awaad… - Journal of Drug Delivery …, 2023 - Elsevier
Celecoxib (CXB), a selective COX-2 inhibitor, is a component of triple-oral-metronomic-
chemotherapy. However, chronic CXB utilization in high doses could bring about major …

Valsartan as a prophylactic treatment against breast cancer development and niche activation: What molecular sequels follow chronic AT-1R blockade?

AMA Mansour, MM Khattab, AS El-Khatib, AK Awaad… - Life Sciences, 2024 - Elsevier
Aims Transactivation of insulin-growth-factor-receptor (IGF-1R) by angiotensin-II-type-1-
receptor (AT-1R) was only demonstrated in vascular-smooth-muscle cells and has never …

Reversal of fibrosis and portal hypertension by Empagliflozin treatment of CCl4-induced liver fibrosis: Emphasis on gal-1/NRP-1/TGF-β and gal-1/NRP-1/VEGFR2 …

AA Noah, NS El-Mezayen, SO El-Ganainy… - European Journal of …, 2023 - Elsevier
To date, liver fibrosis has no clinically approved treatment. Empagliflozin (EMPA), a highly
selective sodium-glucose-cotransporter-2 (SGLT2) inhibitor, has shown ameliorative …

Reactive astrocytes targeting with oral vitamin A: Efficient neuronal regeneration for Parkinson's disease treatment and reversal of associated liver fibrosis

NS El‐Mezayen, MAM Attia, MY Shafik… - CNS Neuroscience …, 2023 - Wiley Online Library
Introduction A recent approach to cure neurodegenerative diseases is to reprogram
fibroblasts into functioning neurons using multiple exogenous transcription factors (TFs) and …

Zolmitriptan niosomal transdermal patches: combating migraine via epigenetic and endocannabinoid pathways and reversal of migraine hypercoagulability

NAH Abou Youssef, GS Labib, AA Kassem… - Drug Delivery and …, 2024 - Springer
Conventional zolmitriptan (ZOL) has limited oral bioavailability, many adverse effects, and
poor membrane penetrability that negatively influences its accessibility to its 5-HT 1B/1D …

Chemometric-enhanced metabolic profiling of different plant parts belonging to two Bougainvillea species using UPLC-MS/MS spectrometry: Correlation to in vitro anti …

AA El-Banna, DA Ghareeb, SA Abdulmalek… - Industrial Crops and …, 2023 - Elsevier
Bougainvillea is considered as an important source of environment-friendly safe pigmenting
agents, namely anthocyanins that are widely used in food, textile, cosmetic, and …

UPLC-MS/MS-based metabolomics decipher anti-inflammatory metabolites from Ziziphus jujuba Mill. and Ziziphus spina-christi L. collected from diverse geographic …

NS El-Gazzar, RS Ibrahim, DA Ghareeb… - South African Journal of …, 2024 - Elsevier
Ziziphus is a cosmopolitan genus that has several traditional applications. One of them is
alleviation of inflammation. However, Ziziphus mechanisms and exact biomarkers in charge …