Intestinal fibrosis is one of the most threatening complications of Crohn's disease. It occurs in
more than a third of patients with this condition, is associated with increased morbidity and …

Extensive tissue fibrosis is the end-stage process of a number of chronic conditions affecting
the gastrointestinal tract, including inflammatory bowel disease (Crohn's disease, ulcerative …

Objective We evaluated the influence of the renin–angiotensin system (RAS) on intestinal
inflammation and fibrosis. Design Cultured human colonic myofibroblast proliferation and …

Background The renin‐angiotensin system (RAS) is a homeostatic pathway widely known to
regulate cardiovascular and renal physiology; however, little is known about its influence in …

Background There is evidence to support a role for angiotensin (Ang) 1–7 in reducing the
activity of inflammatory signaling molecules such as MAPK, PKC and SRC. Enhanced …

Transforming growth factor (TGF)-β, a pleiotropic cytokine released by both immune and non-
immune cells in the gut, exerts an important tolerogenic action by promoting regulatory T cell …

Inflammation is a normal part of the immune response to injury or infection but its
dysregulation promotes the development of inflammatory diseases, which cause …

Background Intestinal fibrosis is the final pathological outcome of chronic intestinal
inflammation without specific therapeutic drugs, which leads to ileus and surgical …

Introduction: The relationship between intestinal inflammation and circulating components of
the renin-angiotensin system (RAS) is poorly understood. Materials and methods …

Transforming growth factor-β (TGF-β) plays a central role in a wide array of cellular functions
including control of cell growth and differentiation, embryonic development, wound healing …