Learning Objectives Explain the characteristics and treatment of malignant peripheral nerve
sheath tumors, both in relation to neurofibromatosis type I and otherwise. Cite the unique …

Genomic and functional study of existing and emerging sarcoma targets, such as fusion
proteins, chromosomal aberrations, reduced tumor suppressor activity, and oncogenic …

Background Sarcomas are rare but aggressive diseases. Specialized multidisciplinary
management is not implemented for all patients in most countries. We investigated the …

Survival outcomes for adolescent and young adult patients with soft tissue sarcomas lag
behind those of children diagnosed with histologically similar tumours. To help understand …

Purpose: Clinical trials with immune checkpoint inhibition in sarcomas have demonstrated
minimal response. Here, we interrogated the tumor microenvironment (TME) of two …

Background No previous reports to date have characterized the national profiles of soft-
tissue sarcomas (STSs). In the present study, we reviewed current practice for STSs in …

Objective To summarize the epidemiology of sarcomas occurring in the head and neck and
identify prognostic factors for patient survival. Study Design and Setting Cross-sectional …

Background Malignant peripheral nerve sheath tumors (MPNST) are a rare subtype of soft
tissue sarcoma. They can arise in irradiated fields, in patients with type 1 neurofibromatosis …

Well-differentiated liposarcoma (WDLPS) is a malignant neoplasia hard to diagnose and
treat. Its main molecular signature is amplification of the MDM2-containing genomic region …

Background Despite curative intents of treatment in localized malignant peripheral nerve
sheath tumours (MPNSTs), prognosis remains poor. This study investigated survival and …