Inflammation constitutes a complex, highly conserved cascade of molecular and cellular
events. Inflammation has been labeled as “the fire within,” is highly regulated, and is critical …

Accumulating clinical evidence has suggested serum triglyceride (TG) is a leading predictor
of atherosclerotic cardiovascular disease, comparable to low-density lipoprotein (LDL) …

The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …

Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor …

Transcription factors of the forkhead box, class O (FoxO) family are important regulators of
the cellular stress response and promote the cellular antioxidant defense. On one hand …

Cardiovascular disease is a major cause of morbidity and mortality in patients with type 2
diabetes mellitus, with a two-to fourfold increase in cardiovascular disease risk compared …

The forkhead box O family consists of FoxO1, FoxO3, FoxO4 and FoxO6 proteins in
mammals. Expressed ubiquitously in the body, the four FoxO isoforms share in common the …

Aging happens to all of us as we live. Thanks to the improved living standard and discovery
of life-saving medicines, our life expectancy has increased substantially across the world in …

Aim To better understand the marked decrease in serum triglycerides observed with
tirzepatide in patients with type 2 diabetes, additional lipoprotein‐related biomarkers were …

Cardiovascular disease (CVD) is the leading cause of death globally. It is well-established
based on evidence accrued during the last three decades that high plasma concentrations …