Innate immunity comprises several inflammation-related modulatory pathways which receive
signals from an array of membrane-bound and cytoplasmic pattern recognition receptors …

The innate immune system in vertebrates and invertebrates relies on conserved receptors
and ligands, and pathways that can rapidly initiate the host response against microbial …

Glyco-immune checkpoint receptors, molecules that inhibit immune cell activity following
binding to glycosylated cell-surface antigens, are emerging as attractive targets for cancer …

Primary interaction of an intracellular bacterium with its host cell is initiated by activation of
multiple signaling pathways in response to bacterium recognition itself or as cellular …

Plant lectins, a natural source of glycans with a therapeutic potential may lead to the
discovery of new targeted therapies. Glycans extracted from plant lectins are known to act as …

The discovery of innate immune sensors (pattern recognition receptors, PRRs) has
profoundly transformed the notion of innate immunity, in providing a mechanistic basis for …

Nuclear receptors are important bridges between lipid signaling molecules and transcription
responses. Beside their role in several developmental and physiological processes, many of …

Innate immunity is one of two immune defence system arms. It is present at birth and does
not require 'learning'through exposure to foreign organisms. It activates various mechanisms …

Absent in melanoma 2 (AIM2)-like receptors (ALRs) are a newly characterized class of
pathogen recognition receptors (PRRs) involved in cytosolic and nuclear pathogen DNA …

Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the colon and
rectum. UC's pathogenesis involves colonic epithelial cell abnormalities and mucosal barrier …