A critical review of traditional and advanced characterisation tools to drive formulators towards the rational development of 3D printed oral dosage forms
M Deon, J Dos Santos, DF de Andrade… - International Journal of …, 2022 - Elsevier
The high degree of precision and control of 3D printing has given formulators the autonomy
to engineer sophisticated and personalised medicines, starting a revolution in …
to engineer sophisticated and personalised medicines, starting a revolution in …
Critical aspects involved in lipid dispersion and digestion: emphasis on in vitro models and factors influencing lipolysis of oral lipid based formulations
Understanding the mechanisms underlying the dispersion and digestion process is vital in
the development of oral lipid-based formulations (LBFs). In vitro lipolysis models mimic the …
the development of oral lipid-based formulations (LBFs). In vitro lipolysis models mimic the …
Establishment of In Vitro Dissolution Based on Similarity with In Vivo Dissolution: A Case Study on Aripiprazole
In vitro dissolution that predicts the in vivo performance of solid preparations is extremely
important in formulation optimization. Fraction absorbed (F a) has been used to screen in …
important in formulation optimization. Fraction absorbed (F a) has been used to screen in …
Enhanced biopharmaceutical performance of brick dust molecule nilotinib via stabilized amorphous nanosuspension using a facile acid–base neutralization approach
M Chougule, A Sirvi, V Saini, M Kashyap… - Drug Delivery and …, 2023 - Springer
Abstract “Brick dust” compounds have high lattice energy as manifested by the poor
aqueous solubility and suboptimal bioavailability. Nilotinib being a weakly basic brick dust …
aqueous solubility and suboptimal bioavailability. Nilotinib being a weakly basic brick dust …
Supersaturating lipid-based solid dispersion of atazanavir provides enhanced solubilization and supersaturation in the digestive aqueous phase
Understanding and controlling the drug solubilization in digestive environment is of great
importance in the design of lipid based solid dispersion (LBSD) for oral delivery of poorly …
importance in the design of lipid based solid dispersion (LBSD) for oral delivery of poorly …
Supersaturable self-emulsifying drug delivery system: a strategy for improving the loading and oral bioavailability of quercetin
Supersaturable Lipid based drug delivery systems have gained much attention as bio-
enabling formulation approach for oral delivery of drugs with high dose. Hence, the present …
enabling formulation approach for oral delivery of drugs with high dose. Hence, the present …
Crystallization inhibitory effects of konjac glucomannan, sodium alginate and xanthan gum on curcumin in supersaturated solution
B Tian, L Li, K Kang, D Peng, Y Shi, P Wang - International Journal of …, 2023 - Elsevier
Supersaturating drug delivery system (SDDS) is a promising approach to enhance the
solubility of hydrophobic functional components. However, SDDS is thermodynamically …
solubility of hydrophobic functional components. However, SDDS is thermodynamically …
Supersaturable diacyl phospholipid dispersion for improving oral bioavailability of brick dust molecule: A case study of Aprepitant
This study aims to investigate the potential use of polymer inclusion in the phospholipid-
based solid dispersion approach for augmenting the biopharmaceutical performance of …
based solid dispersion approach for augmenting the biopharmaceutical performance of …
Revealing the roles of polymers in supersaturation stabilization from the perspective of crystallization behaviors: A case of nimodipine
P Zhao, G Hu, H Chen, M Li, Y Wang, N Sun… - International Journal of …, 2022 - Elsevier
Formulating drugs into amorphous solid dispersions (ASDs) represents an attractive means
to enhance the aqueous solubility of drugs. Furthermore, water-soluble polymers have …
to enhance the aqueous solubility of drugs. Furthermore, water-soluble polymers have …
Fused Deposition Modelling 3D printing and solubility improvement of BCS II and IV active ingredients–A narrative review
A Roche, NM Sanchez-Ballester, B Bataille… - Journal of Controlled …, 2024 - Elsevier
In the field of pharmaceutical research and development, Fused Deposition Modelling
(FDM) 3D printing (3DP) has aroused growing interest within the last ten years. The use of …
(FDM) 3D printing (3DP) has aroused growing interest within the last ten years. The use of …