Pyridine compounds with antimicrobial and antiviral activities

M Marinescu, CV Popa - International journal of molecular sciences, 2022 - mdpi.com
In the context of the new life-threatening COVID-19 pandemic caused by the SARS-CoV-2
virus, finding new antiviral and antimicrobial compounds is a priority in current research …

Chemical synthesis and molecular docking study of new thiazole, thiophene, and thieno [2, 3-d] pyrimidine derivatives as potential antiproliferative and antimicrobial …

IMM Othman, ZM Alamshany, NY Tashkandi… - Journal of Molecular …, 2022 - Elsevier
This context deals with the design and synthesis of a new set of derivatives containing
thiazole, thiophene, and thieno [2, 3-d] pyrimidine motifs 3-13 starting with 2-((2 …

Synthesis and biological evaluation of new derivatives of thieno-thiazole and dihydrothiazolo-thiazole scaffolds integrated with a pyrazoline nucleus as anticancer and …

IMM Othman, ZM Alamshany, NY Tashkandi… - RSC …, 2022 - pubs.rsc.org
Deregulation of various protein kinases is considered as one of the important factors
resulting in cancer development and metastasis, thus multi-targeting the kinase family is one …

Design and synthesis of ciprofloxacin-sulfonamide hybrids to manipulate ciprofloxacin pharmacological qualities: Potency and side effects

NM Ibrahim, SH Fahim, M Hassan, AE Farag… - European Journal of …, 2022 - Elsevier
Fluoroquinolones are a class of antibacterial agents used clinically to treat a wide array of
bacterial infections. Although being potent, susceptibility to CNS side effects limits their use …

New Quinazolin-4(3H)-one Derivatives Incorporating Hydrazone and Pyrazole Scaffolds as Antimicrobial Agents Targeting DNA Gyraze Enzyme

EM Mohi El-Deen, ES Nossier, EA Karam - Scientia Pharmaceutica, 2022 - mdpi.com
The present work includes the synthesis of a new series of quinazolin-4 (3 H)-one
compounds (4a–f, 5a–d) as antimicrobial agents. The starting compound, 2 …

In vitro antimicrobial evaluation and in silico studies of coumarin derivatives tagged with pyrano-pyridine and pyrano-pyrimidine moieties as DNA gyrase inhibitors

EA Fayed, ES Nosseir, A Atef, SA El‑Kalyoubi - Molecular Diversity, 2022 - Springer
Several coumarin-containing substitute nitrogen heterocycles have recently received
considerable importance due to their diverse pharmacological properties. One-pot and rapid …

New thiophene, thienopyridine and thiazoline-based derivatives: Design, synthesis and biological evaluation as antiproliferative agents and multitargeting kinase …

ZM Alamshany, NY Tashkandi, IMM Othman… - Bioorganic …, 2022 - Elsevier
Multitargeting kinase inhibitors recently proved to be a profitable approach for conquering
cancer proliferation. The current study represents the design and synthesis of new …

Synthesis, molecular docking, and biofilm formation inhibitory activity of bis (indolyl) pyridines analogues of the marine alkaloid nortopsentin

HM Abo-Salem, HA Abd El Salam, A Abdel-Aziem… - Molecules, 2021 - mdpi.com
An efficient and simple protocol for the synthesis of a new class of diverse bis (indolyl)
pyridines analogues of the marine alkaloid nortopsentin has been reported. A one-pot four …

Recent advances in the synthesis of five‐and six‐membered heterocycles as bioactive skeleton: A concise overview

N Jangir, Poonam, S Dhadda, DK Jangid - ChemistrySelect, 2022 - Wiley Online Library
Heterocyclic compounds play a tremendous role in the field of medicinal chemistry due to
their association with diverse pharmacological properties. Most of the pharmaceutical drugs …

[HTML][HTML] New thieno [2, 3-b] pyridine-based compounds: Synthesis, molecular modelling, antibacterial and antifungal activities

NA Alenazi, H Alharbi, AF Qarah, A Alsoliemy… - Arabian Journal of …, 2023 - Elsevier
Abstract New thieno [2, 3-b] pyridine clubbed various thiazole ring systems were
synthesized by the reaction of 2-(1-(3-amino-4, 6-dimethylthieno [2, 3-b] pyridin-2-yl) …