Chemically modified and conjugated antimicrobial peptides against superbugs
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …
Lessons learned from clinical trials using antimicrobial peptides (AMPs)
GS Dijksteel, MMW Ulrich, E Middelkoop… - Frontiers in …, 2021 - frontiersin.org
Antimicrobial peptides (AMPs) or host defense peptides protect the host against various
pathogens such as yeast, fungi, viruses and bacteria. AMPs also display immunomodulatory …
pathogens such as yeast, fungi, viruses and bacteria. AMPs also display immunomodulatory …
Development and challenges of antimicrobial peptides for therapeutic applications
More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have
been approved by the US Food and Drug Administration (FDA). Now commercialized, these …
been approved by the US Food and Drug Administration (FDA). Now commercialized, these …
Antimicrobial peptides under clinical investigation
HB Koo, J Seo - Peptide Science, 2019 - Wiley Online Library
Overuse of conventional antibiotics as well as the slow pace of new antibiotic drug
development leads to antimicrobial resistance (AMR). Because infections with multi‐drug …
development leads to antimicrobial resistance (AMR). Because infections with multi‐drug …
Antimicrobial peptides and their therapeutic potential for bacterial skin infections and wounds
A Pfalzgraff, K Brandenburg, G Weindl - Frontiers in pharmacology, 2018 - frontiersin.org
Alarming data about increasing resistance to conventional antibiotics are reported, while at
the same time the development of new antibiotics is stagnating. Skin and soft tissue …
the same time the development of new antibiotics is stagnating. Skin and soft tissue …
Deep learning improves antimicrobial peptide recognition
Motivation Bacterial resistance to antibiotics is a growing concern. Antimicrobial peptides
(AMPs), natural components of innate immunity, are popular targets for developing new …
(AMPs), natural components of innate immunity, are popular targets for developing new …
Microbiological aspects of root canal infections and disinfection strategies: an update review on the current knowledge and challenges
J Wong, D Manoil, P Näsman, GN Belibasakis… - Frontiers in Oral …, 2021 - frontiersin.org
The oral cavity is the habitat of several hundreds of microbial taxa that have evolved to
coexist in multispecies communities in this unique ecosystem. By contrast, the internal tissue …
coexist in multispecies communities in this unique ecosystem. By contrast, the internal tissue …
A bioinformatic study of antimicrobial peptides identified in the Black Soldier Fly (BSF) Hermetia illucens (Diptera: Stratiomyidae)
Antimicrobial peptides (AMPs) play a key role in the innate immunity, the first line of defense
against bacteria, fungi, and viruses. AMPs are small molecules, ranging from 10 to 100 …
against bacteria, fungi, and viruses. AMPs are small molecules, ranging from 10 to 100 …
Molecular dynamics simulations of membrane permeability
This Review illustrates the evaluation of permeability of lipid membranes from molecular
dynamics (MD) simulation primarily using water and oxygen as examples. Membrane …
dynamics (MD) simulation primarily using water and oxygen as examples. Membrane …
Action of antimicrobial peptides against bacterial biofilms
Microbes are known to colonize surfaces and form biofilms. These biofilms are communities
of microbes encased in a self-produced matrix that often contains polysaccharides, DNA and …
of microbes encased in a self-produced matrix that often contains polysaccharides, DNA and …