Noise-induced hearing loss

N Natarajan, S Batts, KM Stankovic - Journal of clinical medicine, 2023 - mdpi.com
Noise-induced hearing loss (NIHL) is the second most common cause of sensorineural
hearing loss, after age-related hearing loss, and affects approximately 5% of the world's …

Antioxidant therapy against oxidative damage of the inner ear: Protection and preconditioning

JH Pak, Y Kim, J Yi, JW Chung - Antioxidants, 2020 - mdpi.com
Oxidative stress is an important mechanism underlying cellular damage of the inner ear,
resulting in hearing loss. In order to prevent hearing loss, several types of antioxidants have …

Estrogen receptor β protects against acoustic trauma in mice

I Meltser, Y Tahera, E Simpson… - The Journal of …, 2008 - Am Soc Clin Investig
The hormone estradiol affects the auditory system both by itself and by its interaction with
neuroprotective factors. In this study, we examined the role of estrogen receptors (ERs) in …

Stress response in rat brain after different durations of noise exposure

J Samson, R Sheeladevi, R Ravindran… - Neuroscience …, 2007 - Elsevier
The alteration in the levels of plasma corticosterone, brain norepinephrine (NE), and
expression of brain heat shock proteins (Hsp70) after different durations of noise exposure …

Novel oral multifunctional antioxidant prevents noise-induced hearing loss and hair cell loss

GD Chen, DM Daszynski, D Ding, H Jiang, T Woolman… - Hearing research, 2020 - Elsevier
Oxidative stress is a major contributor to noise-induced hearing loss, the most common
cause of hearing loss among military personnel and young adults. HK-2 is a potent, orally …

Reversible long-term changes in auditory processing in mature auditory cortex in the absence of hearing loss induced by passive, moderate-level sound exposure

M Pienkowski, JJ Eggermont - Ear and hearing, 2012 - journals.lww.com
Exposure to loud sound can irreversibly damage or destroy peripheral auditory structures,
including the inner hair cells (IHCs) and outer hair cells (OHCs) of the cochlea and the spiral …

Sound conditioning protects hearing by activating the hypothalamic–pituitary–adrenal axis

Y Tahera, I Meltser, P Johansson, H Salman… - Neurobiology of …, 2007 - Elsevier
Sound conditioning primes the auditory system to low levels of acoustic stimuli and reduces
damage caused by a subsequent acoustic trauma. This priming activates the HPA axis …

The DNA methylation inhibitor RG108 protects against noise-induced hearing loss

Z Zheng, S Zeng, C Liu, W Li, L Zhao, C Cai… - Cell Biology and …, 2021 - Springer
Background Noise-induced hearing loss represents a commonly diagnosed type of hearing
disability, severely impacting the quality of life of individuals. The current work is aimed at …

Noise-induced “toughening” effect in wistar rats: enhanced auditory brainstem responses are related to calretinin and nitric oxide synthase upregulation

JC Alvarado, V Fuentes-Santamaría… - Frontiers in …, 2016 - frontiersin.org
An appropriate conditioning noise exposure may reduce a subsequent noise-induced
threshold shift. Although this “toughening” effect helps to protect the auditory system from a …

Solid lipid nanoparticles loaded with edaravone for inner ear protection after noise exposure

G Gao, Y Liu, CH Zhou, P Jiang, JJ Sun - Chinese medical journal, 2015 - journals.lww.com
Background: Antioxidants and the duration of treatment after noise exposure on hearing
recovery are important. We investigated the protective effects of an antioxidant substance …