Hippo effectors YAP/TAZ act as on–off mechanosensing switches by sensing modifications
in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has …

B lymphocytes can suppress immunity through interleukin (IL)-10 production in infectious,
autoimmune, and malignant diseases. Here, we have identified a natural plasma cell subset …

Background Focal adhesion plays an essential role in tumour invasiveness and metastasis.
Hippo component YAP has been widely reported to be involved in many aspects of tumour …

Sequence motifs are short, recurring patterns in DNA that can mediate sequence-specific
binding for proteins such as transcription factors or DNA modifying enzymes. The androgen …

DNA-binding proteins, including transcription factors, epigenetic and chromatin modifiers,
control gene expression in plants. To map the binding sites of DNA-binding proteins in the …

Adult stem cell identity, plasticity, and homeostasis are precisely orchestrated by lineage-
restricted epigenetic and transcriptional regulatory networks. Here, by integrating super …

Histone acetylation, which is an important mechanism to regulate gene expression, is
controlled by the opposing action of histone acetyltransferases and histone deacetylases …

Abstract The Polycomb Group (PcG) proteins form two protein complexes, PcG Repressive
Complex 1 (PRC 1) and PRC 2, which are key epigenetic regulators in eukaryotes. PRC 2 …

The lysine demethylase 3A (KDM3A, JMJD1A or JHDM2A) controls transcriptional networks
in a variety of biological processes such as spermatogenesis, metabolism, stem cell activity …

TET-family dioxygenases catalyze conversion of 5-methylcytosine (5mC) to 5-
hydroxymethylcytosine (5hmC) and oxidized methylcytosines in DNA. Here, we show that …