Carbapenem is an important therapy for serious hospital‐acquired infections and for the
care of patients affected by multidrug‐resistant organisms, specifically Acinetobacter …

Bloodstream infection (BSI) is defined by positive blood cultures in a patient with systemic
signs of infection and may be either secondary to a documented source or primary—that is …

Background Nosocomial pneumonia due to multidrug-resistant Gram-negative pathogens
poses an increasing challenge. We compared the efficacy and safety of cefiderocol versus …

Severe or life threatening infections are common among patients in the intensive care unit
(ICU). Most infections in the ICU are bacterial or fungal in origin and require antimicrobial …

Abstract The French Society of Intensive Care Medicine (SRLF), jointly with the French-
Speaking Group of Paediatric Emergency Rooms and Intensive Care Units (GFRUP) and …

Background Early appropriate antibiotic therapy reduces morbidity and mortality of severe
pneumonia. However, the emergence of bacterial resistance requires the earliest use of …

Source control is an important element of the treatment of sepsis and septic shock [1]. Lack
or delay of source control has been associated with worse outcomes for patients with …

Antimicrobial de-escalation (ADE) is defined as the discontinuation of one or more
components of combination empirical therapy, and/or the change from a broad-spectrum to …

The composition of the gut microbiota is highly dynamic and changes according to various
conditions. The gut microbiota mainly includes difficult-to-cultivate anaerobic bacteria, hence …

Methicillin-resistant Staphylococcus aureus (MRSA) has become a rising clinical problem as
its occurrence has increased due to the overuse and misuse of antibiotics. In this work …