Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in
the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice …

Gold nanoparticles (AuNPs) have a rich history in chemistry, dating back to ancient R beg
glasses f an ov or decor er 150 y ati ears ago ve purpose oman times w s. The modern here …

Nanoparticles can be engineered with distinctive composition, size, shape, and surface
chemistry to enable novel techniques in a wide range of biological applications. The unique …

The aim of this study was to determine the size-dependent penetration ability of gold
nanoparticles and the potential application of ultrasmall gold nanoparticles for intranucleus …

We describe the use of gold nanoparticle-oligonucleotide complexes as intracellular gene
regulation agents for the control of protein expression in cells. These oligonucleotide …

Antisense agents are valuable tools to inhibit the expression of a target gene in a sequence‐
specific manner, and may be used for functional genomics, target validation and therapeutic …

Molecules that can specifically silence gene expression are powerful research tools. Much
effort has been put into the development of such molecules and has resulted in the creation …

The design of antisense oligonucleotides containing locked nucleic acids (LNA) was
optimized and compared to intensively studied DNA oligonucleotides, phosphorothioates …

The sequencing of the human genome and the elucidation of many molecular pathways that
are important in disease have provided unprecedented opportunities for the development of …

Short interfering RNA (siRNA) is widely used for studying gene function and holds great
promise as a tool for validating drug targets and treating disease. A critical assumption in …