Hydrogen sulfide has been recently identified as the third biological gasotransmitter, along
with the more well studied nitric oxide (NO) and carbon monoxide (CO). Intensive studies on …

Oxidative stress plays a dominant role in inflammatory skin diseases. Emerging evidence
has shown that the close interaction occurred between oxidative stress and the gut …

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a painful condition,
experienced by patients undergoing chemotherapy with some specific drugs, such as …

When neuropathic pain is maintained long term, it can also lead to the development of
emotional disorders that are even more intense than pain perception and difficult to treat …

Chronic osteoarthritis pain is accompanied by several comorbidities whose treatment has
not been completely resolved. The anti-inflammatory, analgesic, and antidepressant effects …

Rationale Drug combinations are commonly used in pain management, which can produce
potent analgesic effects with reduced dosage and adverse effects. Objective This study was …

Diabetic neuropathy is an important long-term complication of diabetes. This study explored
the hypothesis that hydrogen sulfide (H2S) ameliorates neuropathic pain by controlling …

Chronic pain is a common public health problem and remains an unmet medical need.
Currently available analgesics usually have limited efficacy for the treatment of chronic pain …

Neuropathic pain is often closely associated with nerve injury or inflammation, and the role
of traditional nonsteroidal anti-inflammatory drugs as adjuvants for treating chemotherapy …

Although paclitaxel (PTX) is potent chemotherapeutic agent commonly used in variety of
cancers, in colorectal carcinoma its usage is excluded because of low effectivity. Up to now …