During mouse preimplantation embryo development, totipotent blastomeres generate the
first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In …

Animals use diverse strategies to specify tissue lineages during development. A common
strategy is to partition maternally supplied and localized lineage determinants into …

It has been thought that early inner cell mass (ICM) is a homogeneous population and that
cell position in the ICM leads to the formation of two lineages, epiblast (EPI) and primitive …

Primitive endoderm (PE) and epiblast (EPI) are two lineages derived from the inner cell
mass (ICM) of the E3. 5 blastocyst. Recent studies showed that EPI and PE progenitors …

Mouse pre-implantation development gives rise to the blastocyst, which is made up of at
least three distinct cell types: the trophectoderm (TE) that surrounds a cavity, and an inner …

In the mouse embryo, asymmetric divisions during the 8-16 cell division generate two cell
types, polar and apolar cells, that are allocated to outer and inner positions, respectively …

Generation of inside cells that develop into inner cell mass (ICM) and outside cells that
develop into trophectoderm is central to the development of the early mouse embryo. Critical …

We have examined the synthesis and distribution of the cell adhesion molecule uvomorulin
in mouse preimplantation embryos. Uvomorulin can already be detected on the cell surface …

The first developmental lineage allocation during the generation of the mouse blastocyst is
to outer trophoblast or to inner pluriblast (inner cell mass; ICM) cells. This allocation seems …

Experimental embryology started in the late 1800s asking such questions as whether one of
the first two blastomeres of a 2-cell newt egg can compensate if the other is killed …