Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention

M Picon‐Ruiz, C Morata‐Tarifa… - CA: a cancer journal …, 2017 - Wiley Online Library
Answer questions and earn CME/CNE Recent decades have seen an unprecedented rise in
obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than …

Macrophages in age-related chronic inflammatory diseases

Y Oishi, I Manabe - NPJ aging and mechanisms of disease, 2016 - nature.com
Chronic inflammation is the common pathological basis for such age-associated diseases
as cardiovascular disease, diabetes, cancer and Alzheimer's disease. A multitude of bodily …

[HTML][HTML] Long-term follow-up of the E1199 phase III trial evaluating the role of taxane and schedule in operable breast cancer

JA Sparano, F Zhao, S Martino, JA Ligibel… - Journal of Clinical …, 2015 - ncbi.nlm.nih.gov
Long-Term Follow-Up of the E1199 Phase III Trial Evaluating the Role of Taxane and
Schedule in Operable Breast Cancer - PMC Back to Top Skip to main content NIH NLM Logo …

Obesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium

CM Olsen, CM Nagle, DC Whiteman… - Endocrine-related …, 2013 - erc.bioscientifica.com
Whilst previous studies have reported that higher BMI increases a woman's risk of
developing ovarian cancer, associations for the different histological subtypes have not …

[HTML][HTML] Cyclooxygenase-2 and the inflammogenesis of breast cancer

RE Harris, BC Casto, ZM Harris - World journal of clinical oncology, 2014 - ncbi.nlm.nih.gov
Cohesive scientific evidence from molecular, animal, and human investigations supports the
hypothesis that constitutive overexpression of cyclooxygenase-2 (COX-2) is a ubiquitous …

Understanding nuclear receptor form and function using structural biology

F Rastinejad, P Huang, V Chandra… - Journal of …, 2013 - jme.bioscientifica.com
In mammals, secretin is a 27-amino acid peptide that was first studied in 1902 by Bayliss
and Starling from the extracts of the jejunal mucosa for its ability to stimulate pancreatic …

GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state

G Sharma, C Hu, JL Brigman, G Zhu… - …, 2013 - academic.oup.com
Estrogen is an important regulator of metabolic syndrome, a collection of abnormalities
including obesity, insulin resistance/glucose intolerance, hypertension, dyslipidemia, and …

[HTML][HTML] Obesity, diabetes, and survival outcomes in a large cohort of early-stage breast cancer patients

S Jiralerspong, ES Kim, W Dong, L Feng… - Annals of oncology, 2013 - Elsevier
Background To determine the relationship between obesity, diabetes, and survival in a large
cohort of breast cancer patients receiving modern chemotherapy and endocrine therapy …

The impact of vitamin D in breast cancer: genomics, pathways, metabolism

CJ Narvaez, D Matthews, E LaPorta… - Frontiers in …, 2014 - frontiersin.org
Nuclear receptors exert profound effects on mammary gland physiology and have complex
roles in the etiology of breast cancer. In addition to receptors for classic steroid hormones …

Impact of body mass index on neoadjuvant treatment outcome: a pooled analysis of eight prospective neoadjuvant breast cancer trials

C Fontanella, B Lederer, S Gade, M Vanoppen… - Breast cancer research …, 2015 - Springer
Obesity is associated with an increased risk of breast cancer (BC) and poorer outcome. We
assessed the impact of body mass index (BMI) on pathological complete response (pCR) …