The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …

The enteric nervous system is a dense network of enteric neurons and glia housed in the
gastrointestinal tract. This system is responsible for performing several functions that enable …

Purinergic signalling plays major roles in the physiology and pathophysiology of digestive
organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive …

P2X7 receptors are members of the ATP-gated cationic channel family with a preferential
localization at the microglial cells, the resident macrophages of the brain. However, these …

The P2X7 receptor is a trimeric ligand-gated cation channel activated by extracellular
adenosine 5′-triphosphate. The study of animals has greatly advanced the investigation of …

This study sought to examine the co-expression of the following purinergic receptor
subunits: P2X1, P2X1del, P2X4, and P2X7 and characterize the P2X response in human …

The enteric nervous system (ENS) commands moment‐to‐moment gut functions through
integrative neurocircuitry housed in the gut wall. The functional continuity of ENS networks is …

Aims Almost every eukaryotic cell releases ATP under certain conditions. The idea that ATP
induces the release of ATP has been scantly investigated. Methods We explored this …

The article will begin with the discovery of purinergic inhibitory neuromuscular transmission
in the 1960s/1970s, the proposal for purinergic cotransmission in 1976 and the recognition …

Background and purpose ATP plays an important role as an extracellular messenger acting
via different types of purinoceptors. Whereas most of the actions of ATP at intestinal epithelia …