Molecular Machines that Facilitate Bacterial Outer Membrane Protein Biogenesis

MT Doyle, HD Bernstein - Annual Review of Biochemistry, 2024 - annualreviews.org
Almost all outer membrane proteins (OMPs) in Gram-negative bacteria contain a β-barrel
domain that spans the outer membrane (OM). To reach the OM, OMPs must be translocated …

Outer membrane lipoproteins: late to the party, but the center of attention

KL May, M Grabowicz - Journal of Bacteriology, 2024 - journals.asm.org
An outer membrane (OM) is the hallmark feature that is often used to distinguish “Gram-
negative” bacteria. Our understanding of how the OM is built rests largely on studies of …

A minimum functional form of the Escherichia coli BAM complex constituted by BamADE assembles outer membrane proteins in vitro

Z Wang, Y Chu, Q Li, X Han, L Zhao, H Zhang… - Journal of Biological …, 2024 - ASBMB
The biogenesis of outer membrane proteins is mediated by the β-barrel assembly machinery
(BAM), which is a heteropentomeric complex composed of five proteins named BamA-E in …

[HTML][HTML] Förster Resonance Energy Transfer Measurements in Living Bacteria for Interaction Studies of BamA with BamD and Inhibitor Identification

S Schreiber, J Jose - Cells, 2024 - mdpi.com
The β-barrel assembly machinery (BAM) is a multimeric protein complex responsible for the
folding of outer membrane proteins in gram-negative bacteria. It is essential for cell survival …

Bam complex associated proteins in Escherichia coli are functionally linked to peptidoglycan biosynthesis, membrane fluidity and DNA replication

JA Bryant, KA Staunton, HM Doherty, MB Alao, X Ma… - bioRxiv, 2023 - biorxiv.org
Biogenesis of the bacterial outer membrane is key to bacterial survival and antibiotic
resistance. Central to this is the β-barrel assembly machine (Bam) complex and its …

The N-terminal extension region of BamE coordinates interaction between the β-barrel domain of BamA and BamD for efficient assembly

Y Maruno, EM Germany, Y Nakajima, R Ohyama… - bioRxiv, 2024 - biorxiv.org
In the Gram-negative bacteria, the assembly of β-barrel proteins into the outer membrane is
mediated by the β-barrel Assembly Machinery (BAM) complex. BamA is a central component …

Insights into the complex formation of a trimeric autotransporter adhesin with a peptidoglycan-binding periplasmic protein

S Yoshimoto, A Suzuki, J Kanie, K Koiwai, AN Lupas… - bioRxiv, 2023 - biorxiv.org
Trimeric autotransporter adhesin (TAA) is an outer membrane (OM) protein that is widely
distributed in gram-negative bacteria and is involved primarily in adhesion to biotic and …