Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic,
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …

The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …

Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

Stimulator of interferons genes (STING), which is crucial for the secretion of type I interferons
and proinflammatory cytokines in response to cytosolic nucleic acids, plays a key role in the …

The suppression of types I and III interferon (IFN) responses by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) contributes to the pathogenesis of coronavirus …

Cell death and immune response are at the core of life. In past decades, the endoplasmic
reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a …

The cGAS-STING pathway mediates cytoplasmic DNA-triggered innate immunity. STING
activation is initiated by cyclic-GMP-AMP (cGAMP)-induced translocation from the …

Stimulator of interferon genes (STING) is an intracellular sensor of cyclic di-nucleotides
involved in the innate immune response against pathogen-or self-derived DNA. STING …

Pharmacology-based methods that promote antitumor immunity have the potential to be
highly efficacious while avoiding the systemic cytotoxicity associated with traditional …

The cGAS–STING pathway is an evolutionarily conserved immune signaling pathway critical
for microbial defense. Unlike other innate immune pathways that largely rely on stationary …