Obesity phenotypes, diabetes, and cardiovascular diseases

ME Piché, A Tchernof, JP Després - Circulation research, 2020 - Am Heart Assoc
This review addresses the interplay between obesity, type 2 diabetes mellitus, and
cardiovascular diseases. It is proposed that obesity, generally defined by an excess of body …

[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

[HTML][HTML] Semaglutide in patients with heart failure with preserved ejection fraction and obesity

MN Kosiborod, SZ Abildstrøm, BA Borlaug… - … England Journal of …, 2023 - Mass Medical Soc
Background Heart failure with preserved ejection fraction is increasing in prevalence and is
associated with a high symptom burden and functional impairment, especially in persons …

Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets

BA Borlaug, MD Jensen, DW Kitzman… - Cardiovascular …, 2022 - academic.oup.com
Obesity and heart failure with preserved ejection fraction (HFpEF) represent two
intermingling epidemics driving perhaps the greatest unmet health problem in …

Impact of epicardial adipose tissue on cardiovascular haemodynamics, metabolic profile, and prognosis in heart failure

NR Pugliese, F Paneni, M Mazzola… - European journal of …, 2021 - Wiley Online Library
Aims We evaluated the impact of echocardiographic epicardial adipose tissue (EAT) on
cardiovascular haemodynamics, metabolic profile and prognosis in heart failure (HF) using …

Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review

A Pandey, SJ Shah, J Butler, DL Kellogg Jr… - Journal of the American …, 2021 - jacc.org
Exercise intolerance (EI) is the primary manifestation of chronic heart failure with preserved
ejection fraction (HFpEF), the most common form of heart failure among older individuals …

Diastolic dysfunction and heart failure with preserved ejection fraction: understanding mechanisms by using noninvasive methods

M Obokata, YNV Reddy, BA Borlaug - JACC: Cardiovascular Imaging, 2020 - jacc.org
Research in the last decade has substantially advanced our understanding of the
pathophysiology of heart failure with preserved ejection fraction (HFpEF). However …

Hemodynamic and functional impact of epicardial adipose tissue in heart failure with preserved ejection fraction

KE Koepp, M Obokata, YNV Reddy, TP Olson… - Heart Failure, 2020 - jacc.org
Objectives This study determined the impact of excess epicardial adipose tissue (EAT) in
patients with the obese phenotype of heart failure with preserved ejection fraction (HFpEF) …

Highlights in heart failure

D Tomasoni, M Adamo, CM Lombardi… - ESC heart …, 2019 - Wiley Online Library
Heart failure (HF) remains a major cause of mortality, morbidity, and poor quality of life. It is
an area of active research. This article is aimed to give an update on recent advances in all …

Exercise testing in heart failure with preserved ejection fraction: an appraisal through diagnosis, pathophysiology and therapy–A clinical consensus statement of the …

M Guazzi, M Wilhelm, M Halle… - European journal of …, 2022 - Wiley Online Library
Patients with heart failure with preserved ejection fraction (HFpEF) universally complain of
exercise intolerance and dyspnoea as key clinical correlates. Cardiac as well as …