Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019
DJ Newman, GM Cragg - Journal of natural products, 2020 - ACS Publications
This review is an updated and expanded version of the five prior reviews that were
published in this journal in 1997, 2003, 2007, 2012, and 2016. For all approved therapeutic …
published in this journal in 1997, 2003, 2007, 2012, and 2016. For all approved therapeutic …
[HTML][HTML] Current update on intrinsic and acquired colistin resistance mechanisms in bacteria
Colistin regained global interest as a consequence of the rising prevalence of multidrug-
resistant Gram-negative Enterobacteriaceae. In parallel, colistin-resistant bacteria emerged …
resistant Gram-negative Enterobacteriaceae. In parallel, colistin-resistant bacteria emerged …
Mechanisms and clinical relevance of bacterial heteroresistance
Antibiotic heteroresistance is a phenotype in which a bacterial isolate contains
subpopulations of cells that show a substantial reduction in antibiotic susceptibility …
subpopulations of cells that show a substantial reduction in antibiotic susceptibility …
[HTML][HTML] Colistin Resistance in Acinetobacter baumannii: Molecular Mechanisms and Epidemiology
K Novović, B Jovčić - Antibiotics, 2023 - mdpi.com
Acinetobacter baumannii is recognized as a clinically significant pathogen causing a wide
spectrum of nosocomial infections. Colistin was considered a last-resort antibiotic for the …
spectrum of nosocomial infections. Colistin was considered a last-resort antibiotic for the …
Prevalence and Some Possible Mechanisms of Colistin Resistance Among Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa
RM Abd El-Baky, SM Masoud… - Infection and Drug …, 2020 - Taylor & Francis
Background and Aim The emergence of colistin-resistant strains is considered a great threat
for patients with severe infections. Here, we investigate the prevalence and some possible …
for patients with severe infections. Here, we investigate the prevalence and some possible …
How antibiotics work together: molecular mechanisms behind combination therapy
GJ Sullivan, NN Delgado, R Maharjan… - Current opinion in …, 2020 - Elsevier
Highlights•Combination therapy is an important tool for tackling antibiotic resistance.•In
depth molecular studies for combination therapy are lacking.•We summarise six major …
depth molecular studies for combination therapy are lacking.•We summarise six major …
[HTML][HTML] In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens
The emergence of multidrug resistant (MDR) pathogenic bacteria is jeopardizing the value
of antimicrobials, which had previously changed the course of medical science. In this study …
of antimicrobials, which had previously changed the course of medical science. In this study …
[HTML][HTML] adeABC efflux gene in Acinetobacter baumannii
CF Xu, SR Bilya, W Xu - New microbes and new infections, 2019 - Elsevier
The antimicrobial resistance to Acinetobacter baumannii is significantly high and continues
to grow; it has become a global health issue, particularly in regards to carbapenem …
to grow; it has become a global health issue, particularly in regards to carbapenem …
Reversing resistance to counter antimicrobial resistance in the World Health Organisation's critical priority of most dangerous pathogens
H Venter - Bioscience reports, 2019 - portlandpress.com
The speed at which bacteria develop antimicrobial resistance far outpace drug discovery
and development efforts resulting in untreatable infections. The World Health Organisation …
and development efforts resulting in untreatable infections. The World Health Organisation …
Colistin heteroresistance in Acinetobacter spp.: systematic review and meta-analysis of the prevalence and discussion of the mechanisms and potential therapeutic …
S Karakonstantis, I Saridakis - International journal of antimicrobial agents, 2020 - Elsevier
Background: Colistin is one of the few remaining options for carbapenem-resistant
Acinetobacter baumannii (A. baumannii); however, emergence of resistance from …
Acinetobacter baumannii (A. baumannii); however, emergence of resistance from …