Natural killer (NK) cells, a crucial component of the innate immune system, have long been
of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is …

Cytokines are major regulators of innate and adaptive immunity that enable cells of the
immune system to communicate over short distances. Cytokine therapy to activate the …

Cancer immunotherapy modulates immune cells to induce antitumor immune responses.
Tumors employ immune checkpoints to evade immune cell attacks. Immune checkpoint …

Cytokines that control the immune response were shown to have efficacy in preclinical
murine cancer models. Interferon (IFN)-α is approved for treatment of hairy cell leukemia …

Colorectal cancer (CRC), as a prominent cause of cancer-related deaths, has historically
been notable worldwide and many attempts have been made to raise the overall survival of …

Throughout the last decade, interventions to engineer the immune system called
immunotherapy have revolutionized the fields of oncology and autoimmune disease …

The broad success of adoptive immunotherapy to treat human cancer has resulted in a
paradigm shift in modern medicine. Modification of autologous and allogenic immune cells …

Cytokine networks are crucial aspects of tumour immunology, particularly for colorectal
cancer (CRC), in which inflammation and antitumour immunity are key determinants of …

Recent years have seen a renaissance in the research linking inflammation and cancer with
immune cells playing a central role in smouldering inflammation in the tumor …

We completed clinical trials of rhIL-15 by bolus, subcutaneous, and continuous intravenous
infusions (CIV). IL-15 administered by CIV at 2 mcg/kg/day yielded a 38-fold increase in 10 …