Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy
S Ma, MA Caligiuri, J Yu - Trends in immunology, 2022 - cell.com
Natural killer (NK) cells, a crucial component of the innate immune system, have long been
of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is …
of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is …
Cytokines in the treatment of cancer
KC Conlon, MD Miljkovic… - Journal of Interferon & …, 2019 - liebertpub.com
Cytokines are major regulators of innate and adaptive immunity that enable cells of the
immune system to communicate over short distances. Cytokine therapy to activate the …
immune system to communicate over short distances. Cytokine therapy to activate the …
M1 macrophage-derived nanovesicles potentiate the anticancer efficacy of immune checkpoint inhibitors
Cancer immunotherapy modulates immune cells to induce antitumor immune responses.
Tumors employ immune checkpoints to evade immune cell attacks. Immune checkpoint …
Tumors employ immune checkpoints to evade immune cell attacks. Immune checkpoint …
Cytokines in cancer immunotherapy
TA Waldmann - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
Cytokines that control the immune response were shown to have efficacy in preclinical
murine cancer models. Interferon (IFN)-α is approved for treatment of hairy cell leukemia …
murine cancer models. Interferon (IFN)-α is approved for treatment of hairy cell leukemia …
[HTML][HTML] PD-1/PD-L1 blockade as a novel treatment for colorectal cancer
N Yaghoubi, A Soltani, K Ghazvini… - Biomedicine & …, 2019 - Elsevier
Colorectal cancer (CRC), as a prominent cause of cancer-related deaths, has historically
been notable worldwide and many attempts have been made to raise the overall survival of …
been notable worldwide and many attempts have been made to raise the overall survival of …
[HTML][HTML] Hydrogel-enabled, local administration and combinatorial delivery of immunotherapies for cancer treatment
Throughout the last decade, interventions to engineer the immune system called
immunotherapy have revolutionized the fields of oncology and autoimmune disease …
immunotherapy have revolutionized the fields of oncology and autoimmune disease …
[HTML][HTML] Use of cell and genome modification technologies to generate improved “off-the-shelf” CAR T and CAR NK cells
MA Morgan, H Büning, M Sauer… - Frontiers in …, 2020 - frontiersin.org
The broad success of adoptive immunotherapy to treat human cancer has resulted in a
paradigm shift in modern medicine. Modification of autologous and allogenic immune cells …
paradigm shift in modern medicine. Modification of autologous and allogenic immune cells …
Emerging cytokine networks in colorectal cancer
Cytokine networks are crucial aspects of tumour immunology, particularly for colorectal
cancer (CRC), in which inflammation and antitumour immunity are key determinants of …
cancer (CRC), in which inflammation and antitumour immunity are key determinants of …
[HTML][HTML] Targeting immune cells for cancer therapy
SY Gun, SWL Lee, JL Sieow, SC Wong - Redox biology, 2019 - Elsevier
Recent years have seen a renaissance in the research linking inflammation and cancer with
immune cells playing a central role in smouldering inflammation in the tumor …
immune cells playing a central role in smouldering inflammation in the tumor …
[HTML][HTML] IL-15 in the combination immunotherapy of cancer
We completed clinical trials of rhIL-15 by bolus, subcutaneous, and continuous intravenous
infusions (CIV). IL-15 administered by CIV at 2 mcg/kg/day yielded a 38-fold increase in 10 …
infusions (CIV). IL-15 administered by CIV at 2 mcg/kg/day yielded a 38-fold increase in 10 …